James (thigh) and Havertz (illness) were both withdrawn from international duty midway through the break, and the duo form part of 10 separate fitness headaches for the depleted Blues.
Armando Broja and Thiago Silva are guaranteed to miss out, while doubts persist over all of Wesley Fofana, Edouard Mendy, Cesar Azpilicueta, Raheem Sterling, Mason Mount and Pierre-Emerick Aubameyang.
While Mendy is closing in on a return from a fractured finger, Kepa Arrizabalaga should continue in goal regardless, and Marc Cucurella could deputise for Fofana alongside Benoit Badiashile and Kalidou Koulibaly.
James is only thought to have pulled out from England duty as a precaution, and so he may be fit enough to bomb down the right here, as Ben Chilwell takes his place on the left.
N'Golo Kante is in line for his first Premier League minutes since August, but he will certainly not be selected from the off, as Mateo Kovacic and Enzo Fernandez resume their partnership.
Christian Pulisic lasted just over an hour during a rare start against Everton, so Mykhaylo Mudryk may now be considered for a start alongside Joao Felix and Havertz - assuming the latter recovers from the flu in time.
Chelsea possible starting lineup: Kepa; Badiashile, Koulibaly, Cucurella; James, Fernandez, Kovacic, Chilwell; Mudryk, Havertz, Felix
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