Rigobert Song's men are the fourth-lowest ranked nation in the competition, and enter Group G as the underdogs, despite boasting plenty of exciting attacking talent throughout the squad.
Between the sticks, The Indomitable Lions can rely on one of the world's best shot-stoppers in Andre Onana, who has been excellent for Inter Milan since a summer move from Ajax.
In defence, the shock omission of Michael Ngadeu from the squad, despite 68 caps and six years of international experience, has left a clear run for both Jean-Charles Castelletto and Nicolas N'koulou to build on their partnership in central defence.
With two talented strikers at the top of the pitch, we are likely to see Cameroon line up in a 4-4-2, as Martin Hongla joins the impressive Andre-Frank Zambo Anguissa in the midfield, flanked by the attacking talent of Karl Toko Ekambi and Bryan Mbuemo.
Up front, Eric Maxim Choupo-Moting enters the competition as one of the form players in world football, having scored in eight of his last nine appearances for club and country.
Alongside him, Vincent Aboubakar will continue to be a handful for defenders, after his eight-goal haul at the Africa Cup of Nations last year.
Cameroon possible starting lineup: Onana; Tolo, Castelletto, Nkoulou, Fai; Toko Ekambi, Hongla, Anguissa, Mbeumo; Aboubakar, Choupo-Moting