David Moyes' side finished the Premier League season in the bottom half but have been successful in Europe yet again.
The trip to Prague gives West Ham their best opportunity in decades to win a major trophy but have they ever won one before?
talkSPORT.com takes a look…
Have West Ham ever won a major trophy?
West Ham have won four major trophies in their history.
READ MORE ON WEST HAM
West Ham vs Fiorentina LIVE: Irons seek first Euro trophy for 58 years in Conference final
David Moyes latest: Scot could leave West Ham this summer despite European final
The Hammers' first title came in 1964 as they lifted the FA Cup after beating Preston North End in the final.
The next trophy came in European competition as the London side lifted the Cup Winners Cup in 1965 following a win over 1860 Munich.
After a ten-year wait, West Ham then returned to success by winning the FA Cup again in 1975.
Bobby Moore lifted the trophy for the second time on his final appearance at Wembley as the Hammers beat Fulham in the capital.
Most read in Football
Tottenham poised to confirm appointment of Ange Postecoglou as personal terms agreed
Liverpool confident of Mac Allister deal with star keen to play for Klopp
Chelsea told Caicedo transfer fee as Blues set to rival Arsenal and Liverpool
Footage emerges of Postecoglou tearing into players for major mistake and fans like it
The most recent of the major trophies came over 40 years ago in 1980 as they beat Arsenal to win the FA Cup for the third time thanks to a goal from Trevor Brooking.
Since then, West Ham have failed to add to their trophy cabinet but they now have the opportunity to put an end to their long wait for some more silverware.