The Hammers are currently top of Group H with three wins out of three in their maiden campaign in Europe's secondary competition.
David Moyes' in-form side moved six points clear of the rest of the teams in the group with a convincing 3-0 home win over Genk two weeks ago.
West Ham have only lost once in their last nine outings.
Genk v West Ham: Date and time
The Europa League clash is due to take place on Thursday, November 4.
It will be played at The Cegeka Arena in Belgium and kick-off will be at 5:45pm UK time.
West Ham next travel to Austria to take on Rapid Vienna before finishing their group-stage journey at home to Dinamo Zagreb.
Genk v West Ham: TV channel and live stream
The Group H clash will be live on BT Sport 3 with coverage starting at 5:15pm.
BT Sport subscribers can live stream this match via the app on their computer, mobile and tablet devices.
Genk v West Ham: Team news
The hosts will once again be without right-back Daniel Munoz as he serves the last game of his suspension.
Other than that, Genk have a clean bill of health and will be buoyed by the 6-2 win on Saturday that moved them up to seventh in the Belgian league.
West Ham meanwhile have no major issues to contend with as Moyes may use the fixture as a chance to shuffle the pack.
Vladimir Coufal could earn his first start since returning from injury in the penalty shoot-out win over Manchester City in the Carabao Cup.
Genk v West Ham: What has been said?
David Moyes: "The players are doing a great job for me and I am thrilled by it.
"Week in week out they turn up and in the main we are doing good things.
"Overall all the squad whether in the cup, Europe or league all the players are contributing."