The Cottagers have enjoyed a brilliant campaign and a win would see them move level on points with Newcastle and just one point behind Tottenham in the top-four race
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Fulham have won 11 Premier League games, which is only bettered by the current top four, so they will be confident of ending the season in style.
Meanwhile, Wolves have also picked up under Julen Lopetegui but lost 1-0 to Bournemouth in their last game.
That result left the Old Gold three points clear of the relegation zone in 15th place, but a win would see them move six points clear of West Ham in 18th.
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Wolves boast a good recent record against the Cottagers and are unbeaten in their last five Premier League meetings, so we should be in for a good match.
Fulham v Wolves: talkSPORT coverage
This Premier League clash is set to take place on Friday, February 24.
Kick-off at Craven Cottage is scheduled for 8pm.
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talkSPORT will have live and EXCLUSIVE coverage from west London, with Hugh Woozencroft serving as your host.
Commentary will then come from Nigel Adderley and former England Women's striker Lianne Sanderson.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Fulham v Wolves: Team news
The hosts are likely to be without star striker Aleksandar Mitrovic as he battles to overcome a hamstring problem.
Carlos Vinicius set up Manor Solomon for the winner against Brighton last weekend and both will hope to start under the lights.
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But the hosts will definitely be without Neeskens Kebano and Tom Cairney.
Meanwhile, Wolves welcome Mario Lemina back into the squad after serving his one-match ban.
Pedro Neto is also slowly working his way back to full fitness, so could be included in the matchday squad.
But the visitors will be without long-term absentees Sasa Kalajdzic, Hwang Hee-chan, Boubacar Traore and Chiquinho.
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Fulham v Wolves: What has been said?
Wolves boss Lopetegui speaking about the relegation battle: "When I arrived here we were at the bottom and now we are in the middle of the fight.
"There's no space for complacency. We won two matches but it's not enough, we have to fight for 40 points. There's a lot of points in front of us.
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"We know it's very hard to get points in this league, that's why you are able to win each match and lose against any team.
"This is football and this is the Premier League level."
Fulham v Wolves: Match facts
Fulham are winless in their last five Premier League meetings with Wolves (failing to score in the last four) since a 5-0 victory in March 2012 (D2 L3).
Wolves won their last Premier League away game against Fulham 1-0 in April 2021, last winning consecutive top-flight visits to Craven Cottage in December 1962 (three in a row).
Fulham have won four points from their two Friday Premier League games this season (W1 D1), as many as they had in their first six such matches in the competition (W1 D1 L4).
Wolves have lost three of their four Premier League away games played on a Friday, though the exception was a 1-0 victory against Fulham in April 2021.
Since the resumption of the Premier League after the World Cup break, only Manchester United (7) have won more games than Fulham (6). Fulham have won 11 Premier League games in total so far this season, last winning more in a single top-flight campaign in 2011-12 (14).
Wolves have won two of their four Premier League away games under Julen Lopetegui (D1 L1), more than they had in their previous 14 (W1 D3 L10). They last won consecutive league games on the road in February last year (a run of four).
Fulham have kept a clean sheet in each of their last three Premier League games, despite facing 43 shots across these matches. They last recorded four consecutive shutouts in the top-flight in December 2001.
Fulham have the highest expected goals against total in the Premier League this season (41.2) but have conceded just 30 goals. Their difference of conceding 11 fewer goals than their xG against is the highest in the competition so far this term.
All six of Manor Soloman's Premier League games for Fulham have been as a substitute, playing 82 minutes in total. He averages a goal every 41 minutes courtesy of scoring in his last two appearances, while the last Israeli player to score in three consecutive Premier League games was Ronnie Rosenthal in November 1992.
Fulham keeper Bernd Leno has kept seven clean sheets in his 22 Premier League games this season, only keeping more in one of his previous four campaigns in the competition (11 in 35 games in 2020-21).