Los Blancos will enter the contest off the back of a 3-0 success over Brest in the Champions League, with Carlo Ancelotti's side finishing in a playoff spot in the overall table.
The capital giants were 3-0 winners over Real Valladolid in Spain's top flight last weekend, meanwhile, and they are currently top of the La Liga table, four points ahead of second-placed Atletico Madrid.
Here, Sports Mole rounds up Real Madrid's injury and suspension news ahead of the clash with Espanyol, who are 18th in the division, one point behind 17th-placed Alaves.
Eduardo Camavinga
Status: Major doubt
Type of injury: Hamstring
Possible return date: February 1 (vs. Espanyol)
Real Madrid were again without the services of Camavinga on Wednesday evening due to a hamstring injury, but there is a slight chance that the midfielder could be back in the squad against Espanyol this weekend.
Dani Carvajal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Real Madrid will be without the services of Carvajal for the remainder of the 2024-25 campaign due to the severe knee injury that the right-back suffered in the clash with Villarreal on October 5.
Eder Militao
Status: Out
Type of injury: Knee
Possible return date: Unknown
Real Madrid will be without the services of Militao for the remainder of the campaign, as the Brazilian centre-back damaged his ACL during the clash with Osasuna back in November.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no players suspended for the La Liga contest.
Written by
Matt Law