Gianluigi Donnarumma, Nuno Mendes, Lucas Hernandez and Fabian Ruiz were all rested and left out of the PSG squad - crowned Ligue 1 champions on Sunday - that rescued a 3-3 draw with Le Harve on Saturday, but the quartet are in contention to return against Dortmund, with the former in line to replace Keylor Navas between the sticks.
Star striker Kylian Mbappe, who has scored eight of his 43 goals this season in the Champions League, began as a substitute before coming on for the second half against Le Harve, but he is expected to be recalled in attack on Wednesday.
Mbappe will likely be joined in a three-man frontline by wingers Ousmane Dembele and Bradley Barcola, although Goncalo Ramos and Randal Kolo Muani are two more attackers at Enrique's disposal who will be pushing to start.
Marco Asensio could continue in the number 10 role, while 18-year-old starlet Warren Zaire-Emery, who extended his contract over the weekend until 2029, will be hoping to retain his place in centre-midfield alongside Vitinha, who scored both home and away in the quarter-finals against Barcelona.
Lucas Beraldo faces competition from both Hernandez and Mendes to keep his spot at left-back, while Danilo Pereira, Marquinhos and Achraf Hakimi are all expected to continue in the back four.
Three PSG players who will not be involved on Wednesday are Presnel Kimpembe (Achilles), Layvin Kurzawa (back), Sergio Rico (head) as they continue to recover from injury.
Paris Saint-Germain possible starting lineup: Donnarumma; Hakimi, Marquinhos, Danilo, Hernandez; Vitinha, Zaire-Emery; Dembele, Asensio, Barcola; Mbappe