The Eagles have failed to win any of their first six top-flight matches of the season, and last weekend's 2-1 loss to Everton leaves Oliver Glasner's men in the drop zone, albeit only behind Leicester City on goals scored.
Meanwhile, Slot became the first Liverpool manager in history to win eight of their opening nine matches in charge on Wednesday evening, where the Reds defeated Bologna 2-0 in the Champions League for their fifth straight victory in all competitions.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 64
Crystal Palace wins: 15
Draws: 13
Liverpool wins: 36
A fixture that does not boast the richest head-to-head history, Crystal Palace and Liverpool have met on 64 occasions down the years, beginning with the Reds winning a 1937-38 FA Cup third-round tie after a replay.
That victory marked the first of 36 successes for the Merseyside giants in this matchup, while Palace have earned a respectable 15 wins of their own, and another 13 battles have ended in a split of the spoils.
The Eagles managed to claim their most recent triumph over Liverpool as recently as April 2024, where a solitary Eberechi Eze strike silenced the Anfield faithful in a 1-0 win for Glasner's men, whose victory was a crushing blow to the Reds' title hopes.
Palace ended a miserable 13-match winless run against Liverpool with that surprise Anfield victory over the Easter period, and the Reds have only prevailed in one of their last four games against the Eagles, although it did come at Selhurst Park in the 2023-24 season.
The two sides accepted a point apiece in both meetings during the 2022-23 campaign, prior to which Liverpool had overcome Palace 10 times in a row in the top flight, a sequence that includes their 7-0 mauling of Roy Hodgson's side at Selhurst Park in December 2020.
Palace's stadium has been a happy hunting ground for Liverpool in the Premier League era, as they have won eight and drawn one of their last nine top-flight matches at Selhurst Park, where they are undefeated since a 3-1 defeat in November 2014.
However, the ground was also the site of Luis Suarez's tearful outburst earlier that year, as Brendan Rodgers's Liverpool remarkably threw away a three-goal lead to draw 3-3 with Palace, a result that effectively handed Manchester City the title.
Nevertheless, Palace's 38 home goals conceded to Liverpool - and 69 overall - are their worst records against a single opponent in the Premier League, and Sadio Mane leads the way in terms of individual strikes against Palace with 10, but Mohamed Salah (eight) is not far behind.
Last 20 meetings
Apr 14, 2024: Liverpool 0-1 Crystal Palace (Premier League)
Dec 09, 2023: Crystal Palace 1-2 Liverpool (Premier League)
Feb 25, 2023: Crystal Palace 0-0 Liverpool (Premier League)
Aug 15, 2022: Liverpool 1-1 Crystal Palace (Premier League)
Jan 23, 2022: Crystal Palace 1-3 Liverpool (Premier League)
Sep 18, 2021: Liverpool 3-0 Crystal Palace (Premier League)
May 23, 2021: Liverpool 2-0 Crystal Palace (Premier League)
Dec 19, 2020: Crystal Palace 0-7 Liverpool (Premier League)
Jun 24, 2020: Liverpool 4-0 Crystal Palace (Premier League)
Nov 23, 2019: Crystal Palace 1-2 Liverpool (Premier League)
Jan 19, 2019: Liverpool 4-3 Crystal Palace (Premier League)
Aug 20, 2018: Crystal Palace 0-2 Liverpool (Premier League)
Mar 31, 2018: Crystal Palace 1-2 Liverpool (Premier League)
Aug 19, 2017: Liverpool 1-0 Crystal Palace (Premier League)
Apr 23, 2017: Liverpool 1-2 Crystal Palace (Premier League)
Oct 29, 2016: Crystal Palace 2-4 Liverpool (Premier League)
Mar 06, 2016: Crystal Palace 1-2 Liverpool (Premier League)
Nov 08, 2015: Liverpool 1-2 Crystal Palace (Premier League)
May 16, 2015: Liverpool 1-3 Crystal Palace (Premier League)
Feb 14, 2015: Crystal Palace 1-2 Liverpool (FA Cup Fifth Round)
Last 10 Premier League meetings
Apr 14, 2024: Liverpool 0-1 Crystal Palace (Premier League)
Dec 09, 2023: Crystal Palace 1-2 Liverpool (Premier League)
Feb 25, 2023: Crystal Palace 0-0 Liverpool (Premier League)
Aug 15, 2022: Liverpool 1-1 Crystal Palace (Premier League)
Jan 23, 2022: Crystal Palace 1-3 Liverpool (Premier League)
Sep 18, 2021: Liverpool 3-0 Crystal Palace (Premier League)
May 23, 2021: Liverpool 2-0 Crystal Palace (Premier League)
Dec 19, 2020: Crystal Palace 0-7 Liverpool (Premier League)
Jun 24, 2020: Liverpool 4-0 Crystal Palace (Premier League)
Nov 23, 2019: Crystal Palace 1-2 Liverpool (Premier League)
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