The England international unsurprisingly took his place on the right wing for the Selhurst Park London derby after starting on the bench in Wednesday's 3-2 EFL Cup quarter-final victory.
Saka made an immediate impact in the capital, as his early corner missed its intended targets in the middle but fell kindly for Gabriel Jesus, who fired home after notching a hat-trick in midweek.
However, midway through the first half, the 23-year-old then hurt himself after delivering another ball to the box, and he was seen clutching the back of his thigh and gesturing to the dugout.
Saka stayed down near the corner flag while Arsenal built up from the back again, and Jesus eventually kicked the ball out of play to allow his teammate to be assessed, and he cut an abject figure on the turf.
Saka shook his head a couple of times while being attended to by the physio and gingerly made his way to the sideline, while receiving an earful by Palace defender Maxence Lacroix over the time he was taking.
Mikel Arteta sent on Leandro Trossard to replace Saka, who has now emerged as an early doubt for Arsenal's clash with Ipswich Town on December 27, and the Gunners boss will no doubt be asked for a post-game update.
Written by
Ben Knapton