Both teams are the only ones with a 100% record in the Liga MX this term but at least one of them will have to relinquish their perfect start here.
Match preview
Cruz Azul were firing on all cylinders as they claimed a comprehensive 4-0 win over Monterrey in Sunday's meeting at Estadio BBVA Bancomer.
Martin Anselmi's men opened the scoring through Ignacio Rivero after which a Carlos Rotondi double put the result beyond doubt but there was still time for Angel Sepulveda to get in on the act late on.
Consequently, Los Celestes have moved up to top spot in the Liga MX table, albeit only on goal difference.
Awaiting them next is the challenge of an opposing outfit with little to choose from over the last five clashes which have yielded two wins apiece and one draw.
Unbeaten in all but one of their last seven home matches, Wednesday's hosts have been formidable in front of their fans lately and will be confident of a positive outcome here.
Club Tijuana emerged victorious from a six-goal thriller against Guadalajara Chivas which ended 4-2 at Estadio Caliente on Saturday.
Goals from Domingo Blanco and Jose Zuniga saw Juan Osorio's men cruising at half time but their lead was soon cut short by Cade Cowell after which Christian Rivera and Zuniga sealed the deal, rendering Armando Gonzalez's effort inconsequential.
Having picked up maximum points from their two games so far, El Xolaje sit second in the standings, level on points at the summit with their next opponents.
Since a seven-game winless away run from late January to late March, Wednesday's visitors have won two of the following three matches on the road and seem to have turned their away fortunes around.
Cruz Azul Liga MX form:
W
L
D
L
W
W
Club Tijuana Liga MX form:
L
W
W
L
W
W
Team News
Cruz Azul's Camilo Candido missed his side's emphatic win over Monterrey through suspension but is eligible to feature here.
Following his two-goal haul in the aforementioned game, forward Carlos Rotondi heads into this one on a high and will be looking to deliver the goods once again.
Gabriel Fernandez has not featured since February due to a knee injury which is set to keep him out of Wednesday's affair as well.
Tijuana's Domingo Blanco will be seeking to find the back of the net for a third successive game in keeping with his fine form to start the campaign.
Cruz Azul possible starting lineup:
Mier; Piovi, Lira, Ditta, Sanchez; Faravelli, Rodriguez, Rivero; Rotondi, Torres, Giakoumakis
Club Tijuana possible starting lineup:
Corona; Mejia, Inzunza, Gomez, Bilbao; Vega, Castaneda, Reynoso; Blanco, Gonzalez, Zuniga