ARSENAL
Gameweek 16 opponents: Aston Villa (A)
Out: Thomas Partey (thigh), Fabio Vieira (groin), Jurrien Timber (knee), Emile Smith Rowe (knee), Takehiro Tomiyasu (calf)
Doubtful: None
Mikel Arteta quotes: "I think everybody is going to be OK.
"We don't know [when Thomas Partey will be back], it's a bit early to get a time frame. If he's back by Christmas then it will be very fast. We're missing key players but we have to continue."
ASTON VILLA
Gameweek 16 opponents: Arsenal (H)
Out: Emiliano Buendia (knee), Tyrone Mings (knee), Bertrand Traore (muscle)
Doubtful: None
Unai Emery quotes: "We had to rest a lot - we played on Sunday and last Thursday as well. The players are at the beginning [of their preparation] so I do not have all the information on some injuries.
"It is going to be very important, the last day [of preparation] and tomorrow for all players to tell me physically and emotionally how they are for tomorrow."
BOURNEMOUTH
Gameweek 16 opponents: Man United (A)
Out: Tyler Adams (thigh), Alex Scott (knee), Ryan Fredericks (calf), Max Aarons (hamstring), Emiliano Marcondes (ankle), Darren Randolph (ill), Lloyd Kelly (muscle), Hamed Traore (ill)
Doubtful: None
Andoni Iraola quotes: "For me, this game is not an easy one to choose a starting XI. When we have played three games in previous weeks, the third one has probably been the worst - Brentford, Arsenal and Manchester City.
"I know we almost won against Brentford but we were not at our best physically. The players have trained well since Palace and everyone looks like they have recovered well. But we have to think because we need to be energetic and fresh.
"We arrived home very late from Palace and, straight away, the next morning you are showing the players videos of United. You have to make them think 'okay, you haven't slept well and you are tired but you have these guys waiting for you in a few hours.
"It's difficult and mentally demanding. The big teams are used it because they play every three or four days when they are in Europe."
BRENTFORD
Gameweek 16 opponents: Sheffield United (A)
Out: Rico Henry (knee), Aaron Hickey (hamstring), Ivan Toney (suspended), Kevin Schade (adductor), Nathan Collins (ankle), Kristoffer Ajer (foot), Bryan Mbeumo (ankle)
Doubtful: Joshua Dasilva (hamstring), Mathias Jensen (adductor)
Thomas Frank quotes: "[The Bryan Mbeumo injury] is bad. He'll have a scan later, but we don't know the exact number of weeks he will be out. He will definitely not play on Saturday [against Sheffield United], and he will be out for weeks. We will know more in the next couple of days.
"[Bryan] must be number two after Ivan [Toney] in terms of goals and assists, which is key. His work rate for the team is incredible; you don't see many wingers who work so hard and mean so much. He's become the key man - 'Give me the ball, I'll take this'. Who will that man be now? We'll find out in the next weeks.
"Football is such a marginal game - inside of the post, outside of the post, deflection - there are so many things that you can't control. And another thing is injuries. We need to do everything we can to recover well, assess and get players back, but there's also just bad luck in it.
"Bryan's injury is a clear one - it's bad luck. He got caught, got pushed and rolled his ankle. It's very frustrating, but I'm a positive guy and we'll find a solution.
"The positive news is that [Mikkel] Damsgaard got minutes [against Brighton] and is looking better and better. [Mathias] Jensen will be a decision I need to make in the next 24 hours, whether I want to push him to be ready or be a little more cautious and have him ready for Villa. I will assess him in the next 24 hours."
BRIGHTON & HOVE ALBION
Gameweek 16 opponents: Burnley (H)
Out: Danny Welbeck (unspecified), Solly March (knee), Julio Enciso (knee), Pervis Estupinan (thigh), Tariq Lamptey (thigh), Ansu Fati (thigh), Adam Webster (knock)
Doubtful: None
Roberto De Zerbi quotes: "[Adam] Webster is still unavailable to play. I don't know when he will play.
"But it's important for us that [Lewis] Dunk and Mo [Dahoud] are available because they're both very important, especially in this moment. We are going through a difficult moment in terms of injuries and having two players available is important.
"The news about Ansu Fati is that he needs three months from the injury. It's bad news for us because he was playing better, he was understanding better the idea. I am sorry for him and the team especially now when Welbeck is not playing, Enciso is not playing."
BURNLEY
Gameweek 16 opponents: Brighton (A)
Out: Lyle Foster (mental health), Luca Koleosho (knee), Jack Cork (calf)
Doubtful: Josh Cullen (knock)
Vincent Kompany quotes: "It's bad news for us, [Koleosho]'s going to be out for a while apparently. I can't really share the medical details but it appears in the collision he did something to his knee.
"We think he's going to be long-term fine, but short-term we have to give him the time to recover.
"We will do everything we can to make sure he will get back healthy and ready to go again. The key concern now is to make sure he doesn't sustain any long-term damage because he's still young, so we're going to do everything that is right by him."
CHELSEA
Gameweek 16 opponents: Everton (A)
Out: Wesley Fofana (knee), Ben Chilwell (thigh), Trevoh Chalobah (thigh), Carney Chukwuemeka (knee), Lesley Ugochukwu (unspecified)
Doubtful: Christopher Nkunku (knee), Romeo Lavia (ankle), Malo Gusto (tendon), Noni Madueke (unspecified)
Mauricio Pochettino quotes: "We are still assessing [Nkunku] day-by-day. I don't believe that he will be involved [against Everton] but we need to assess day-by-day.
"I think we are trying to optimise the players we have and then we need to be calm because when you suffering these types of things it's about being calm.
I am disappointed because we wanted to win against Manchester United and I think we were close. Of course they started really good, they showed more energy than us. They were more clinical. It's about dealing with the situation, we can't complain and have to face the reality.
"It's a little thing that's part of a component. It's the composition of the squad, we need to find a good balance on the pitch and the inconsistency came from a different part of the team. The challenge was to settle everything and to behave like a team. For different circumstances we are a little late."
CRYSTAL PALACE
Gameweek 16 opponents: Liverpool (H)
Out: Jesurun Rak-Sakyi (thigh), Dean Henderson (thigh), Eberechi Eze (ankle), Cheick Doucoure (Achilles), Rob Holding (ankle), Tyrick Mitchell (hip)
Doubtful: None
Roy Hodgson quotes: "Tyrick Mitchell] is injured, so he is another one that we have lost but that we're ill-equipped to lose in this moment in time with [Cheick] Doucoure and [Ebere] Eze still out of the team.
"Our injury list isn't enormously long, it's just that three of the players we are missing are three regular players in the team.
"Mitchell was a hip injury which came as a result of a contusion which has provoked a hip injury. This game was definitely too quick coming around for him to be considered, but that doesn't mean that he won't be considered for the next game."
EVERTON
Gameweek 16 opponents: Chelsea (H)
Out: Dele Alli (groin)
Doubtful: Amadou Onana (calf), Andre Gomes (calf), James Garner (illness), Jordan Pickford (knee), Seamus Coleman (knock)
Sean Dyche quotes: "Jimmy [Garner], I hope [will be available]. It's a sickness bug and you never know, they can pass very quickly but there are some longer ones. We hope it's a 24-hour situation, so he'd have time to get food back in himself and feel stronger again.
"Amadou [Onana], we're hoping will be around it - possibly in the squad. We'll just have to wait and see how the next couple of days of training go.
"We'll check on Seamus tomorrow. He has a minor situation, we think, which is unfortunate but that can happen. He has been out a long time. It's great to have him back, he wore the armband with pride like he does.
"[Pickford] has just got a niggly thing on his knee. I'll find out more tomorrow, you never like to talk about it until you find out 24 to 48 hours later. I don't think it's anything too serious."
FULHAM
Gameweek 16 opponents: West Ham (H)
Out: Issa Diop (ankle), Tyrese Francois (unspecified)
Doubtful: Rodrigo Munoz (knee), Adama Traore (hamstring)
Marco Silva quotes: "Adama Traore and Rodrigo Muniz are much closer to returning. After tomorrow's session, I'll take a decision on them both."
LIVERPOOL
Gameweek 16 opponents: Crystal Palace (A)
Out: Thiago Alcantara (hip), Stefan Bajcetic (calf), Andrew Robertson (shoulder), Diogo Jota (leg), Joel Matip (ankle)
Doubtful: Alisson Becker (hamstring), Alexis Mac Allister (knee)
Jurgen Klopp quotes: "Alisson is back in training from Thursday, he trained normally. He's doing well, but I don't know about him being ready for tomorrow.
"[Alexis Mac Allister] doesn't look good. We'll have to see day by day. They were hopeful after the game that it was not that serious, but in this period of the year you're out for five days and that's 12 games. I don't expect him to be ready for tomorrow.
"We have known for four or five days Joel will be out for a long time. We have four centre-backs already. That's alright. If we had five in already, that's a completely different team dynamic with one not involved.
"If we can go with those four, great, if not then it will be a bit more tricky. Unless other clubs put a world-class centre-back under the Christmas tree for us, I don't think so to be honest."
LUTON TOWN
Gameweek 16 opponents: Man City (H)
Out: Mads Andersen (hamstring), Dan Potts (hamstring), Reece Burke (hamstring), Issa Kabore (ineligible)
Doubtful: Cauley Woodrow (calf), Tom Lockyer (back), Albert Sambi Lokonga (hamstring), Marvelous Nakamba (knee), Chiedozie Ogbene (hamstring)
Rob Edwards quotes: "We're hoping that Tom Lockyer will be back available which is great news.