On Tuesday night, the Italian completely rotated his side for the EFL Cup tie with Barrow, handing rests of many of his key players.
Reverting back to the team that started against West Ham United last weekend was a possibility, but Maresca has instead opted to tinker with a winning side.
Having recovered from a thigh injury and proven his fitness in midweek, Malo Gusto has been restored to his role at right-back.
Rather than keep Tosin Adarabioyo in the centre of defence, Maresca has moved Wesley Fofana back inside to partner Levi Colwill.
The remainder of the team is as expected, with Christopher Nkunku's hat-trick versus Barrow not enough to earn him a start in the final third.
On the substitutes' bench, Romeo Lavia is a notable returnee after a thigh injury, with Kiernan Dewsbury-Hall the player to drop out of the squad.
Brighton make three changes
Despite possessing an unbeaten record, Brighton boss Fabian Hurzeler has decided to make three alterations from the team that started against Nottingham Forest last weekend.
Adam Webster, Fedri Kadioglu and Mats Wieffer have been brought into the team at centre-back, left-back and central midfield respectively.
Jan Paul van Hecke, Joel Veltman and Simon Adingra are the trio to make way.
Chelsea XI: Sanchez; Gusto, Fofana, Colwill, Cucurella; Caicedo, Fernandez; Madueke, Palmer, Sancho; Jackson
Subs:: Jorgensen, Disasi, Tosin, Veiga, Lavia, Neto, Mudryk, Felix, Nkunku
Brighton XI: Verbruggen; Kadioglu, Webster, Dunk, Estupinan; Hinshelwood, Baleba; Wieffer, Rutter, Mitoma; Welbeck
Subs: Steele, Lamptey, Igor, Enciso, Moder, Minteh, Ayari, Ferguson, Samuels