The Catalan outfit entered the November international break off the back of a 1-0 defeat to Real Sociedad, but they remain top of the La Liga table, six points ahead of second-placed Real Madrid.
Hansi Flick's side have played a game more than the reigning champions, though, and they will be desperate for their strong start to the season not to go to waste, making this a hugely important fixture.
Here, Sports Mole rounds up Barcelona's injury and suspension news ahead of the clash with Celta, who sit 11th in Spain's top flight, boasting 17 points from their first 13 games of the season.
Ronald Araujo
Status: Out
Type of injury: Hamstring
Possible return date: December 3 (vs. Mallorca)
Araujo will again miss out for Barcelona against Celta, but the centre-back has revealed that he is making excellent progress in his recovery from a hamstring operation, with his return set to come in early December.
Andreas Christensen
Status: Out
Type of injury: Achilles
Possible return date: Unknown
Christensen remains on the treatment table with an Achilles problem, and it has been reported that the Denmark international has had a setback in his recovery, with the defender set to be missing for at least another couple of months.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Bernal suffered an ACL injury against Rayo Vallecano in the league earlier this term, and he is out for the season, with the youngster working to be ready for pre-season ahead of the 2025-26 campaign.
Marc-Andre ter Stegen
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona will be missing their number one goalkeeper Ter Stegen for the remainder of the season due to the serious knee injury that he suffered in the clash with Villarreal on September 22.
Ferran Torres
Status: Major doubt
Type of injury: Thigh
Possible return date: November 23 (vs. Celta)
Barcelona have been without the services of versatile forward Torres due to the thigh problem that he suffered during his side's clash with Alaves before the October international break, but there is a slight chance that the Spaniard could be back this weekend.
Eric Garcia
Status: Minor doubt
Type of injury: Muscle
Possible return date: November 23 (vs. Celta Vigo)
Barcelona have been without Garcia for their last five matches due to a muscular problem, but the Spaniard is in the latter stages of his recovery and could be back in the squad this weekend.
Lamine Yamal
Status: Major doubt
Type of injury: Ankle
Possible return date: November 23 (vs. Celta Vigo)
Yamal was absent against Real Sociedad last time out and also did not represent Spain during the international break due to an ankle problem, but there is a slight chance that the 17-year-old could be back in the squad for this match.
Ansu Fati
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Barcelona revealed last week that Fati had picked up a thigh problem during a training session, and the attacker now faces a battle to be available before the winter break in Spain.
Robert Lewandowski
Status: Minor doubt
Type of injury: Back
Possible return date: November 23 (vs. Celta Vigo)
Lewandowski did not represent Poland during the international break due to a back problem, and the striker will now need to be assessed before it is decided whether he will take on Celta this weekend.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for the La Liga clash.