The Galician hosts head into matchday 36 in 18th position, while Los Leones are sitting in fifth place after collecting 61 points from 35 matches.
Match preview
Celta suffered a third consecutive away defeat at the weekend despite putting in a determined display in their away meeting with fourth-placed Atletico Madrid.
Claudio Giraldez's side kept Atleti at bay until the 84th minute when Rodrigo De Paul scored a sensational winner to condemn Celta to their 17th league defeat of the season - only Granada and Almeria have lost more games in La Liga this term.
Despite falling to add to their 34-point tally, Celta still have a sizeable five-point buffer between themselves and Cadiz ahead of their final three fixtures against Athletic, Granada and Valencia.
With Celta looking to extend their 12-year stay in the top flight, they can secure mathematical safety on matchday 36 if they beat Athletic and Cadiz lose to Sevilla.
Los Celestes may only have the fourth-best home record in the division, but they have fared well in recent outings at Balaidos, having won three of their previous four matches in front of their supporters.
After winning their last two home matches, Celta now have the opportunity to claim three consecutive home league wins for the first time since the 2020-21 season.
Since winning the Copa del Rey, Athletic have experienced an inconsistent run of league form, with their last five matches producing one win, three draws and one defeat.
Los Leones managed to show great fight to salvage a 2-2 draw in Saturday's home clash with Osasuna thanks to Inaki Williams's 58th-minute effort and Asier Villalibre's stoppage-time equaliser.
Although rescued a point, Athletic's Champions League hopes were all but ended by Atletico Madrid's 1-0 win over Celta Vigo, leaving the Basque side eight points adrift of the top four with three games left to play.
Los Leones can still be proud of the fact that they are on the verge of securing Europa League qualification and a fifth-placed finish, which would represent their best La Liga season since 2015-16.
Athletic's success has been built upon a foundation of strong defence which has conceded just 35 league goals in as many matches - only champions Real Madrid have let in fewer this season.
Athletic were not at their defensive best in November's reverse fixture, but they still had the firepower required to claim a 4-3 win over Celta at San Mames.
Celta Vigo La Liga form:
D
L
W
L
W
L
Athletic Bilbao La Liga form:
L
D
D
L
W
D
Athletic Bilbao form (all competitions):
W
D
D
L
W
D
Team News
Mihailo Ristic missed the defeat to Atletico due to an ankle problem, and the left-back is unlikely to recover for the midweek clash with Athletic.
Joseph Aidoo remains a long-term absentee, but Carles Perez and Williot Swedberg should be available after returning to training.
Celta legend Iago Aspas will be one of the home side's main attacking outlets after scoring three goals in the last two matches at Balaidos.
Meanwhile, Gorka Guruzeta underwent appendix surgery earlier this month and will not feature in any of Athletic's final three matches.
Oihan Sancet and Inigo Ruiz de Galarreta have stepped up their respective recoveries, but the pair are unlikely to be involved in Wednesday's away fixture.
Left-back Yuri Berchiche will drop out of the squad to serve a one-match suspension after picking up his fifth yellow card of the season.
In positive news, Yeray Alvarez and Aitor Paredes are back from suspension, with the latter set to partner Dani Vivian in central defence.
Celta Vigo possible starting lineup:
Guaita; Nunez, Starfelt, Jailson; Mingueza, Beltran, Rodriguez, Alvarez; Aspas, Swedberg, Larsen
Athletic Bilbao possible starting lineup:
Simon; De Marcos, Paredes, Vivian, Lekue; Prados, Vesga; I Williams, Muniain, N Williams; Villalibre
We say: Celta Vigo 1-1 Athletic Bilbao
Athletic have won just two of their last eight away league games, and we think that they will have to settle for a draw against a Celta side that has avoided defeat in each of their previous four home matches.