The Red Devils have dropped to 13th in the table after defeats either side of the international break and are already nine points adrift.
Erik ten Hag's side were beaten 3-1 by Brighton to make it three defeats from four games in the Premier League.
Vincent Kompany will also be itching to score bragging rights over his former rivals as the Man City legend seeks a big upset.
Burnley vs Man United: talkSPORT coverage
This Premier League clash will take place on Saturday, September 23.
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Kick-off at Turf Moor is scheduled for 8pm.
talkSPORT will have live coverage of the showdown in Lancashire, with Faye Carruthers serving as your presenter.
Commentary will then come from Sam Matterface and former England defender Micky Gray.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Burnley vs Man United: Team news
The hosts are without Michael Obafemi and Hjalmar Ekdal due to injury, but Anass Zaroury is back from his three-match suspension.
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Meanwhile, United have been decimated by injuries, with Aaron Wan-Bissaka becoming the latest to be sidelined.
Luke Shaw, Tyrell Malacia, Kobbie Mainoo, Amad Diallo, Tom Heaton and new signing Sofyan Amrabat are all in the treatment room.
United are still without Antony for the immediate future, while Jadon Sancho remains unavailable after a public feud with boss Ten Hag.
But both Mason Mount and Raphael Varane are closing in on comebacks.
Burnley vs Man United: What has been said?
Ten Hag was keen to play down United's mammoth 31-game unbeaten run at Old Trafford coming to an end against Brighton.
He told talkSPORT: "As always, we are disappointed with every game we lose and today it was not necessary to lose because we had our chances and there were really small margins.
"But not on our side, you have to accept that and we have to move forward.
"Keep working hard and stick to the plan, sticking together, that's important as well, and then it will come, we will turn this."