Ralf Rangnick's side are sitting fourth in the table after going three matches unbeaten in the league before the winter break.
But their FA Cup defeat to Middlesbrough on Friday night has put the club under fresh scrutiny, with real emphasis now on kicking on in the Premier League.
For Burnley, this is another huge game as they continue their fight against relegation.
Sitting bottom of the table with three games in hand on 17th place Norwich, they'll be hoping that they can close the three-point gap between them and safety.
Burnley v Manchester United: Date and time
The Premier League fixture is set to take place on Tuesday, February 8 at Turf Moor.
Kick-off is scheduled for 8pm.
United beat Burnley in the reverse of this fixture in December, winning 3-1 at Old Trafford.
Burnley v Manchester United: How to follow
The clash at Turf Moor is set to be televised live on BT Sport 1 with coverage starting at 7pm.
talkSPORT will have regular updates from the Premier League clash during Kick Off with Adrian Durham, with coverage starting at 6pm on talkSPORT 2 before moving to talkSPORT at 7pm.
Meanwhile talkSPORT.com will have all of the action with our live match blog.
Burnley v Manchester United: Team news
Burnley will welcome Josh Brownhill back from suspension for the clash at Turf Moor.
They will, however, be without Matej Vydra and Johann Berg Gudmundsson for the clash, while Ashley Barnes and Charlie Taylor are major doubts.
For United, there could be a number of changes against the Clarets.
David De Gea, Alex Telles, Fred and Anthony Elanga dropped out of the starting line-up for the clash with Middlesbrough and could return.
Jadon Sancho and Bruno Fernandes picked up minor knocks in that game, but should feature.
A decision will be made on Jesse Lingard and Edinson Cavani's involvement, while Eric Bailly and Mason Greenwood will certainly miss out.