Both clubs are gearing up for historic seasons, with the Seagulls playing in Europe and the Magpies returning to the Champions League.
Brighton bounced back from their narrow defeat to Chelsea by downing Brentford 2-0 ahead of their return home.
Roberto De Zerbi's men will play just one more friendly against Rayo Vallecano in England before the new Premier League season starts.
Newcastle will be looking to maintain their unbeaten pre-season run while securing a first win in three games.
Eddie Howe's side have twice came from behind to draw in the USA, holding Chelsea 1-1 days after a 3-3 thriller with Aston Villa.
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Brighton vs Newcastle: Date and how to follow
This Premier League Summer Series clash will take place on Saturday, July 29.
It is being held at New Jersey's Red Bull Arena, with kick-off scheduled for 12:30am in the UK.
The match is set to be broadcast on Sky Sports Main Event and Sky Sports Premier League with coverage starting from 12:20am.
Sky Go customers will be able to stream the match through their laptops or mobile devices.
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Alternatively, fans can purchase a one-day NOW TV membership for £11.99 or a monthly one for £34.99 a month.
talkSPORT will have live updates throughout the evening while talkSPORT.com will be on hand for all the best reaction as well.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
u can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Brighton vs Newcastle: Team news
Moises Caicedo could make his first start of pre-season after appearing from the bench against Brentford amid increased speculation surrounding his future.
James Milner is waiting to make his debut however, while Lewis Dunk and Pervis Estupinan and Facundo Buonanotte face late fitness tests.
As for Newcastle, Harvey Barnes will likely be handed his first start since arriving from Leicester.
Nick Pope will return between the sticks but doubts remain over the fitness of Joe Willock.
Brighton vs Newcastle: What has been said?
De Zerbi was delighted after the win over Brentford after stressing that quality opposition is exactly the preparation that his side need.
"I'm really happy, really delighted for the performances, for the result, for the quality of play," De Zerbi said.
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"It was a very tough game but we knew before the game Brentford is a very good team.
"And we need this game to prepare the start of the Premier League."
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