Brighton smashed Newcastle last weekend and have claimed two handsome cup wins either side of that victory at St James' Park.
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Graham Potter's men will want to build on that when United travel to the south coast in Saturday's lunchtime kick-off.
The Red Devils get their 2020/21 campaign off to a rocky start last weekend, losing 3-1 at home to Crystal Palace.
There is growing unrest among the United faithful following their result and the club's lack of transfer activity this summer.
Solskjaer will need a big performance at Brighton to quiet some of his critics and talkSPORT will be in attendance to bring you all the action exclusively live.
Brighton v Manchester United: How to listen
This match will get under way at 12:30pm on Saturday, September 26.
Full coverage from the AMEX will be live on talkSPORT, with our coverage starting at 11am.
Reshmin Chowdhury will be your host before commentary from Sam Matterface and Mick McCarthy.
To tune in, click the radio player below or HERE for the live stream.
Here are the other ways to listen…
App iPhone - Download from the Apple store
Android - Download from Google Play
Radio - talkSPORT is available across the United Kingdom via DAB digital radio and on 1089 or 1053 AM.
TV - Listen to talkSPORT through your TV on the following channels: Sky: Channel 0108 Virgin Media: Channel 927 Freeview: Channel 723 Freesat: Channel 731
Brighton v Manchester United: Team news
Brighton star Tariq Lamptey should be fit despite suffering a leg injury against Newcastle last weekend.
Yves Bissouma serves the second game of his three-match suspension.
Christian Walton, Jose Izquierdo and Florin Andone remain out injured.
For United, they have no fresh injury concerns and will recall their first-team players after making wholesale changes for their cup clash in midweek.
United's only absentees are defenders Axel Tuanzebe and Phil Jones.
Summer signing Donny van de Beek will be pushing for his first Premier League start.
Brighton v Manchester United: What has been said?
Brighton boss Graham Potter: "Manchester United were probably the best team at that point [in their 3-0 win in Sussex in June], really, really strong.
"It was a difficult night but Solskjaer's that type of character that doesn't get too excited when things go really well and doesn't get too down when things go not so well.
"He's quite consistent in his behaviour and does his best, works hard and waits for the next opportunity."
He added: "The players are in a good place, working for each other," he said.
"The understanding of what we're trying to do is developing, so that's pleasing.
"At the same time, we know how football is. There are challenges around the corner and things can quickly turn around so just try and keep as level as possible and look forward to the next match."
Brighton v Manchester United: Match stats and facts
Brighton have won three of their last four home league games against Manchester United, though they did lose this exact fixture 0-3 last season.
Manchester United have won each of the last three Premier League meetings with Brighton - of all current top-flight sides, only against Leicester (4) are the Red Devils on a longer current winning run.
Brighton have won two of their last three Premier League games (L1), as many as they had in their previous 17 (D9 L6). The Seagulls are looking to pick up back-to-back league wins for the first time since November 2019.
Brighton have won just one of their 10 Premier League home games so far in 2020 (D4 L5), beating Arsenal 2-1 in June. The Seagulls have lost four of their last five at the Amex Stadium (D1), shipping at least three goals in each defeat.
Manchester United haven't lost both of their opening two games in a Premier League season since the inaugural campaign in 1992-93 (1-2 vs Sheffield United, 0-3 vs Everton), when they went on to lift the title.
Manchester United have won their last four Premier League away games by an aggregate score of 10-0. The last Premier League team to win five consecutive away games without conceding were Manchester United themselves in December 2011.
Manchester United haven't won their first away league game in either of the last two seasons (D1 L1), including a 2-3 loss at Brighton in 2018-19.
Neal Maupay was involved in all three of Brighton's goals in their 3-0 win against Newcastle last weekend (2 goals, 1 assist); the Frenchman hadn't scored or assisted more than one goal in a game in any of his previous 38 appearances in the competition.
Pascal Groß has either scored (3) or assisted (1) in each of his last four Premier League appearances against Manchester United, scoring the winning goal in both of Brighton's victories against the Red Devils in the competition.
Against Crystal Palace in their opening match, Bruno Fernandes had the joint-most shots (3), most chances created (5), most touches (123), most passes (94) and open play crosses (6) of any Manchester United player.
Brighton will be looking to continue their good form this weekend and inflict more pain on Ole Gunnar Solskjaer and Manchester United.