Newcastle United await Brighton in their first home game of the season.
All four of Brighton's opening games come against teams with the 'United' suffix.
October presents a difficult month for Brighton, who face Liverpool, Tottenham Hotspur, Manchester City and Chelsea in the space of 29 days.
Brighton's 2022-23 Premier League fixtures in full:
August
7 - Manchester United (A)
13 - Newcastle United (H)
20 - West Ham United (A)
27 - Leeds United (H)
30 - Fulham (A)
September
3 - Leicester City (H)
10 - Bournemouth (A)
17 - Crystal Palace (H)
October
1 - Liverpool (A)
8 - Spurs (H)
15 - Brentford (A)
18 - Nottingham Forest (H)
22 - Manchester City (A)
29 - Chelsea (H)
November
5 - Wolves (A)
12 - Aston Villa (H)
December
26 - Southampton (A)
31 - Arsenal (H)
January
2 - Everton (A)
14 - Liverpool (H)
21 - Leciester City (A)
February
4 - Bournemouth (H)
11 - Crystal Palace (A)
18 - Fulham (H)
25 - Newcastle United (A)
March
4 - West Ham United (H)
11 - Leeds United (A)
18 - Manchester United (H)
April
1 - Brentford (H)
8 - Spurs (A)
15 - Chelsea (A)
22 - Manchester City (H)
25 - Nottingham Forest (A)
29 - Wolves (H)
May
6 - Everton (H)
13 - Arsenal (A)
20 - Southampton (H)
28 - Aston Villa (A)