The Cherries are looking to complete their first league double over the Red Devils after cruising to a surprise 3-0 victory in the reverse fixture at Old Trafford four months ago.
Match preview
Man United's hopes of securing a top-five finish and qualifying for next season's Champions League are hanging by a thread following a disappointing run of just one victory in their last six Premier League games.
Since the international break, the Red Devils have failed to win any of their last three top-flight matches following late drama in a 1-1 draw at Brentford, a 4-3 defeat at Chelsea and a 2-2 draw at home to Liverpool last weekend.
Two stunning second-half strikes from Bruno Fernandes and Kobbie Mainoo put Man United ahead against their title-chasing Merseyside counterparts, but with six minutes remaining, Mohamed Salah restored parity for the visitors from the penalty spot after Aaron Wan-Bissaka lunged in late on Harvey Elliott.
Under the watchful eye of new minority shareholder Sir Jim Ratcliffe, manager Erik ten Hag is under increased pressure to keep his job, if reports are to be believed, as he sees his side sitting sixth in the Premier League table and 11 points adrift of both fifth-placed Aston Villa, who have played a game more, and Tottenham Hotspur in fourth spot.
Although a place in the Europa League beckons for Man United, they do have a favourable set of fixtures on the horizon, with encounters against Sheffield United, Burnley and Crystal Palace to follow Saturday's meeting with Bournemouth, whom they have beaten in four of their last six league games at the Vitality Stadium.
Bournemouth's impressive five-game unbeaten run in the Premier League, including four victories, came to an end last weekend when they let a one-goal lead slip in a 2-1 defeat at Luton Town.
Marcus Tavernier fired the Cherries in front seven minutes after the interval, but the Hatters equalised through Jordan Clark before Carlton Morris tapped home a 90th-minute winner, condemning Andoni Iraola's men to their 12th league loss of the season.
With seven games remaining, Bournemouth have already exceeded last season's points total of 39 (currently on 41) and are in no danger of entering the relegation picture, as they sit 12th in the table and 16 points clear of the bottom three.
The Cherries have only ever managed one top-half finish in their Premier League history (ninth in 2016-17), but a top-seven finish - something that was unimaginable earlier this season - is not out of the question this term as they are only seven points behind West Ham United in seventh, who have played a game more.
Bournemouth will welcome a return to the Vitality Stadium where they have suffered defeat in only two of their last 11 home league matches - losing to Liverpool (4-0) and Man City (1-0). Iraola's side have won each of their last three home games and they have never won four in a row as a top-flight club.
Bournemouth Premier League form:
W
D
W
W
W
L
Manchester United Premier League form:
L
L
W
D
L
D
Manchester United form (all competitions):
L
W
W
D
L
D
Team News
Bournemouth will be without Tavernier, Luis Sinisterra (both thigh) and Ryan Fredericks (calf) due to injury, the former picked up his issue against Luton last weekend, while Tyler Adams (back), Antoine Semenyo (unspecified) and Chris Mepham (illness) will all be assessed ahead of kickoff.
Lloyd Kelly made a welcomed return to the first XI last weekend, while Marcos Senesi was fit to make a substitute appearance in the second half, and both defenders will be in contention to feature on Saturday.
Either Dango Ouattara or Alex Scott could be recalled in the absence of Tavernier, while top scorer Dominic Solanke, who scored one of his 16 Premier League goals this season in the reverse fixture at Old Trafford, is set to lead the line.
As for Man United, Lisandro Martinez (calf), Victor Lindelof (hamstring), Luke Shaw (muscle), Tyrell Malacia (knee), Anthony Martial (groin) all remain unavailable for selection due to injury.
Raphael Varane, Jonny Evans, Scott McTominay (all unspecified) were all absent from the draw with Liverpool, while Marcus Rashford (unspecified) was forced off midway through the second half of that contest, and all four players will be checked over ahead of kickoff, as will Sofyan Amrabat who was not spotted in training on Thursday.
Nineteen-year-old Willy Kambwala could continue in central defence alongside Harry Maguire, while Antony is in line for a recall on the right flank if Rashford is not deemed fit to start.
Bournemouth possible starting lineup:
Neto; Smith, Zabarnyi, Senesi, Kelly; Christie, Cook; Semenyo, Scott, Kluivert; Solanke
Manchester United possible starting lineup:
Onana; Dalot, Kambwala, Maguire, Wan-Bissaka; Casemiro, Mainoo; Antony, Fernandes, Garnacho; Hojlund
We say: Bournemouth 2-2 Manchester United
Man United's character will be tested in the coming weeks as they cannot afford to drop any more points if they are to keep their slim top-five ambitions alive, while Bournemouth could do with returning to winning ways if they are to spark a late push for the top seven.
The Cherries got the better of the Red Devils in comfortable fashion the last time that these two teams met, but we feel that there is little to separate them this time around so they may be forced to share the spoils in a score draw.