Kepa missed the Cherries' 1-1 draw at Aston Villa last weekend due to a "small" thigh injury, but the Chelsea loanee could be ready to return between the sticks at the expense of Mark Travers.
Luis Sinisterra (muscle) and Philip Billing (illness) also missed the draw with Villa and will be assessed ahead of kickoff, while Alex Scott is facing a lengthy spell on the sidelines with a knee injury.
Andoni Iraola will consider recalling Adam Smith at right-back in place of Julian Araujo, while Illia Zabarnyi, Marcos Senesi and Milos Kerkez should all retain their positions in the back four.
Ryan Christie, who scored in a 2-0 win at home to Arsenal a fortnight ago, is expected to link arms with Lewis Cook in centre-midfield, with either Marcus Tavernier or Justin Kluivert set to operate in the number 10 role.
Antoine Semenyo and Dango Ouattara could both start on the flanks for the third successive game, while Evanilson will be hoping to force his way back into the first XI ahead of ex-Man City striker Enes Unal after scoring a late equaliser as a substitute against Villa.
Bournemouth possible starting lineup: Kepa; Smith, Zabarnyi, Senesi, Kerkez; Cook, Christie; Semenyo, Tavernier, Ouattara; Evanilson
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