Roberto Martinez's side enjoyed an easy route to Qatar as they finished unbeaten in the qualifiers, picking up six wins and two draws in eight matches to secure top spot in Group E.
Canada, whose last World Cup appearance came in 1986, ended their 36-year absence from the tournament after finishing as group winners in the CONCACAF qualifiers with 28 points from 14 matches.
Here, Sports Mole looks at how the squads of Belgium and Canada stack up against each other ahead of Wednesday's contest.
BELGIUM
Most valuable player:
Kevin De Bruyne (£69.3m)
Overall squad value:
£487.7m
Most capped player:
Jan Vertonghen (142)
Leading goalscorer:
Romelu Lukaku (68)
Total caps:
1,357
Total goals:
247
Oldest player:
Jan Vertonghen (38)
Youngest player:
Zeno Debast (19)
Average age:
27.8
SQUAD IN FULL
Goalkeepers: Thibaut Courtois (Real Madrid), Simon Mignolet (Club Brugge), Koen Casteels (Wolfsburg)
Defenders: Jan Vertonghen (Anderlecht), Toby Alderweireld (Royal Antwerp), Leander Dendoncker (Aston Villa), Wout Faes (Leicester City), Arthur Theate (Rennes), Zeno Debast (Anderlecht), Yannick Carrasco (Atletico Madrid), Thomas Meunier (Borussia Dortmund), Timothy Castagne (Leicester City), Thorgan Hazard (Borussia Dortmund)
Midfielders: Kevin De Bruyne (Manchester City), Youri Tielemans (Leicester City), Amadou Onana (Everton), Axel Witsel (Atletico Madrid), Hans Vanaken (Club Brugge)
Forwards: Eden Hazard (Real Madrid), Charles De Ketelaere (AC Milan), Leandro Trossard (Brighton & Hove Albion), Dries Mertens (Galatasaray), Jeremy Doku (Rennes), Romelu Lukaku (Inter Milan), Michy Batshuayi (Fenerbahce), Lois Openda (Lens)
CANADA
Most valuable player:
Alphonso Davies (£60.6m)
Overall squad value:
£162.2m
Most capped player:
Atiba Hutchinson (98)
Leading goalscorer:
Cyle Larin (25)
Total caps:
822
Total goals:
125
Oldest player:
Atiba Hutchinson (39)
Youngest player:
Ismael Kone (20)
Average age:
26.9
SQUAD IN FULL
Goalkeepers: Milan Borjan (Red Star Belgrade), Dayne St. Clair (Minnesota United), James Pantemis (CF Montreal)
Defenders: Alistair Johnston (CF Montreal), Sam Adekugbe (Hatayspor), Kamal Miller (CF Montreal), Steven Vitoria (Chaves), Richie Laryea (Toronto), Derek Cornelius (Panetolikos), Joel Waterman (CF Montreal)
Midfielders: Samuel Piette (CF Montreal), Stephen Eustaquio (Porto), Liam Fraser (Deinze), Atiba Hutchinson (Besiktas), Mark-Anthony Kaye (Toronto), Ismael Kone (CF Montreal), Jonathan Osorio (Toronto), David Wotherspoon (St Johnstone)
Forwards: Lucas Cavallini (Vancouver Whitecaps), Junior Hoilett (Reading), Tajon Buchanan (Club Brugge), Ike Ugbo (Troyes), Cyle Larin (Club Brugge), Alphonso Davies (Bayern Munich), Jonathan David (Lille), Liam Millar (Basel)
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