Carlo Ancelotti's side continued their strong run of form with a 3-2 victory over Alaves in La Liga on Tuesday night, with the result moving them onto 17 points from their opening seven games of the season.
Los Blancos are second in the table, four points behind the leaders Barcelona, who have a perfect record from their first seven matches of the 2024-25 campaign.
Here, Sports Mole rounds up Real Madrid's injury and suspension news ahead of their contest with fourth-placed Atletico at Wanda Metropolitano.
David Alaba
Status: Out
Type of injury: Knee
Possible return date: Unknown
Alaba suffered an ACL injury last December, which has required two operations to fix. The centre-back is making solid progress in his recovery, but he will not be back on the field until the end of this year.
Eduardo Camavinga
Status: Minor doubt
Type of injury: Knee
Possible return date: September 29 (vs. Atletico Madrid)
Camavinga suffered a knee injury in a training session ahead of the UEFA Super Cup in August, which has seen him miss the early stages of the new La Liga season, but the midfielder could be back for the Madrid derby.
Dani Ceballos
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Ceballos picked up an ankle injury during Real Madrid's clash with Real Betis before the September international break, and the midfielder will be out for another few weeks.
Brahim Diaz
Status: Out
Type of injury: Abductor
Possible return date: Unknown
Real Madrid will be missing Brahim until at least the middle of November due to the hip abductor injury that he suffered against Real Sociedad after the September international break.
Kylian Mbappe
Status: Out
Type of injury: Thigh
Possible return date: October 19 (vs. Celta Vigo)
Real Madrid will be without the services of their leading goalscorer Mbappe until after the October international break due to the thigh problem that he suffered in the win over Alaves last time out.
Dani Carvajal
Status: Minor doubt
Type of injury: Knock
Possible return date: September 29 (vs. Atletico)
Carvajal was substituted against Espanyol last weekend due to "a knock", and he missed out against Alaves on Tuesday night, but the defender is expected to return for the Madrid derby.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no players suspended for their clash with Atletico.