The England star continued his stunning start to life in Spain after scoring a last-gasp winner against Union Berlin on his Champions League debut for Los Blancos in midweek.
The 20-year-old has now managed six goals in six games for Carlo Ancelotti's side since joining from Borussia Dortmund over the summer.
And Bellingham is expected to be the main man again away at Los Colchoneros, who are already eight points adrift of table-topping Real.
Los Blancos are looking to make it seven straight wins in all competitions this season at the expense of their neighbours.
But Diego Simeone's Atleti will be eager to reverse their recent record in Madrid derbies, having only won one of the past six meetings.
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Atletico Madrid vs Real Madrid: How to follow
This La Liga clash will take place on Sunday, September 24.
Kick-off at the Metropolitano Stadium is scheduled for 8pm UK time.
It will be broadcast live on Viaplay Sports 2 with their coverage starting at 7:30pm.
Fans can subscribe to Viaplay for £14.99 per month and can watch the game on their TV or website.
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Atletico Madrid vs Real Madrid: Team news
The home side have been handed a boost with the news that captain Koke is due to return to ease their hefty injury crisis.
Rodrigo de Paul and Memphis Depay are both doubts, while Caglar Soyuncu, Pablo Barrios and Thomas Lemar are all longer-term absentees.
The visitors are missing several key men of their own, with Vinicius Junior set to miss out after tearing his hamstring.
Dani Carvajal remains a doubt, while Thibaut Courtois, Eder Militao and Arda Guler are all confined to the treatment room as well.
Atletico Madrid vs Real Madrid: What has been said?
Bellingham's former Birmingham City youth coach has claimed the England superstar always had what it took to reach the top.
Speaking exclusively to talkSPORT, Mike Dodds said: "One thing he's always had from a very, very young age, he will never waste a training session, he will never waste a minute in the gym, he will never waste an opportunity to watch his clips back.
"He's just so laser-focused in every area of his programme, he will never leave a stone unturned. If he feels he's got a deficiency in his game, he'll be almost like obsessive with fixing it.
"It's interesting now that we see that kind of quality that he's got in terms of bossing people around, being really driven is a real quality.
"Whereas kind of eight or seven years ago that was seen as, 'Ooo you've got to make sure he's humble, you've got to make sure he slows himself down, you can't talk to people like that.'
"It's like, 'Well he can, because he's got to be able to survive in the first-team dressing room' and listen there were times when he overstepped the mark.
"Of course there was, he was a young boy but what that did do, when we fostered and kind of enhanced that quality that he had, it allowed him at 16 to go in the dressing room and survive and then obviously take that on.
"What you're seeing now is someone that's supremely confident in who they are as a person, he's gone to Madrid and people asked me yesterday, 'What do you see difference [is]?' I think he just looks happy, he looks like he's at a place in terms of Madrid where he feels he belongs."