O'Neil made 10 changes to his side for the League Cup fixture with Brighton, and his team suffered a 3-2 defeat to their fellow Premier League outfit to exit the competition.
The big names will be recalled for this one, with the team expected to be similar to the one that started the Premier League game against Newcastle United last weekend.
Matheus Cunha is set to play as the number 10 behind Jorgen Strand Larsen, with Hwang Hee-chan and Goncalo Guedes potentially having to accept spots on the bench.
Toti Gomes has overcome a hamstring strain and should be involved at the back, but Craig Dawson and Rayan Ait-Nouri both face late fitness tests for the visitors.
Wolves will definitely be without the services of Bastien Meupiyou, Enso Gonzalez, Sasa Kalajdzic and Boubacar Toure, meanwhile, for the visit to Villa Park.
A tough start to the campaign has seen O'Neil's side pick up just one point from four games to sit 18th in the table, and they will be looking to their talented attacking players to provide inspiration this weekend.
Wolverhampton Wanderers possible starting lineup: Johnstone; Semedo, Mosquera, Bueno, Toti; Bellegarde, J. Gomes, Lemina, R. Gomes; Cunha; Larsen