Arsenal sit top of the Premier League table, eight points clear of Manchester City after the Red Devils beat the champions 2-1 at the weekend before the Gunners secured a 2-0 win against Tottenham.
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But if they were to lose to Man United for the second time this season, Erik ten Hag's side would find themselves five points behind Arsenal and well in the title race.
The Red Devils are on a great run but their momentum was slightly halted by a 1-1 draw against Crystal Palace in midweek.
The reverse tie ended in a 3-1 win for Man United despite the hosts being dominated for large spells.
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And Ten Hag's men are a much better side than they were, meaning we should be in for a cracker between the Premier League giants.
Arsenal v Man United: Date and kick-off time
This Premier League clash is scheduled to take place on Sunday, January 22.
Kick-off at the Emirates is set for 4:30pm.
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Arsenal v Man United: How to follow
This huge game will be broadcast on Sky Sports Main Event and Sky Sports Premier League.
Coverage will start at 4pm and Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
Alternatively, fans can purchase a NOW TV one-day pass for £9.99.
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talkSPORT will have live updates throughout, while talkSPORT.com will be running a live blog too.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Arsenal v Man United: Team news
Bukayo Saka managed to shake off a knock to star in the Tottenham win, while Emile Smith Rowe came off the bench for the latter stages with the Gunners close in on having a full squad.
But they will still be without Gabriel Jesus, with the Brazilian still recovering from knee surgery.
However, Eddie Nketiah has performed brilliantly in his place and will lead the line once more.
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Plus, new man Leandro Trossard should be available to make his debut after completing a £27m move from Brighton on Friday.
The visitors have more injury concerns and will definitely be without Donny van de Beek and Axel Tuanzebe.
Diogo Dalot is still struggling with a hamstring problem and Anthony Martial has picked up another knock and will be assessed.
Jadon Sancho has returned to training as he nears his first-team comeback, but it remains to be seen if he'll be included in Sunday's squad.
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Meanwhile, Casemiro will have to sit this one after collecting his fifth league booking of the season against Palace.
Arsenal v Man United: What has been said?
Mikel Arteta speaking after Arsenal's win over Tottenham: "I'm very happy for two reasons.
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"One, because I saw a team with a lot of courage, determination and quality, and that really wanted it today, to come here and win the game. And the other one, because we have a job where we are really privileged that we can make a lot of people happy and when you have this opportunity, you have to try to do it.
"So, the enjoyment of sharing the victory with the fans was a great feeling and then everything that we do, all the suffering, the hours of work, it makes a lot of sense when you have moments like this."
Man United boss Erik ten Hag speaking about Arsenal:
"They deserve to be in the position they're in now.
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"They have a really good structure in the way they play and have a winning mentality and attitude in the team. That's why they are top of the league.
"They are on a great run and it's up to us to beat that run and we will do everything to do that.
"We know what to do. We have to be really good and we need a really good performance. If we do, then we have a good chance of getting a good result."
Arsenal v Man United: Match facts
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Arsenal have scored in 17 of their 18 Premier League games this season, though the exception was their last home game in the competition (0-0 vs Newcastle). They've not failed to score in consecutive league matches at the Emirates Stadium since November 2020.
This is just the third time Arsenal are hosting Manchester United in a Premier League match while top of the table, with the previous two meetings ending in draws - 1-1 in March 2004 and 2-2 in November 2007.
Manchester United won 3-1 against Arsenal in September, with the Gunners top of the table. The only side they've beaten twice in the same Premier League campaign when the opponent was top both times are Newcastle United in 1995-96.
This is the 29th Premier League meeting between Arsenal and Manchester United on a Sunday, with only Chelsea v Liverpool (32) and Liverpool v Man Utd (31) taking place more often on the day. 65% of Arsenal's Premier League victories over the Red Devils have been in Sunday games (11/17).
Man Utd are looking to complete only their second league double over Arsenal since Sir Alex Ferguson retired in 2013, doing so since then only in 2017-18 under José Mourinho.
Arsenal have won five of their last seven home Premier League matches against Manchester United (D1 L1), winning 3-1 at the Emirates last season.
Arsenal's Gabriel Martinelli has been involved in 10 goals in his last 10 Premier League games at the Emirates Stadium (6 goals, 4 assists), only failing to either score or assist a goal in two of his appearances in this run (vs Fulham and Newcastle).
Man Utd's Marcus Rashford has been involved in eight goals in his 10 Premier League starts against Arsenal (4 goals, 4 assists) - against no side has he produced more goal involvements in the Premier League than versus the Gunners.
Bukayo Saka has scored in his last two Premier League games against Man Utd - only Freddie Ljungberg (1998-2000) and Thierry Henry (2000-2001) have scored in three in a row for Arsenal against the Red Devils in the competition.
Arsenal are yet to concede a goal in 2023, drawing 0-0 with Newcastle before wins against Oxford (3-0) and Tottenham (2-0). In only three calendar years have the Gunners not conceded in any of their first four competitive matches, doing so in 1935, 1994 and 2021.