The Gunners secured an uncomfortable 2-1 victory over Nottingham Forest on the opening weekend, where first-half strikes from Eddie Nketiah and Bukayo Saka proved telling.
Mikel Arteta's men opened the 2022-23 season with a 2-0 triumph over Palace at Selhurst Park, but they have already been hit with a devastating early blow on the fitness front.
Here, Sports Mole rounds up Arsenal's injury and suspension news ahead of the clash with the Eagles, who bested Sheffield United 1-0 in gameweek one.
Jurrien Timber
Status: Out
Type of injury: Knee
Possible return date: Unknown
Summer signing Jurrien Timber left the field after just 50 minutes on his Premier League debut last weekend, and scans have shown a serious ACL injury - which will require surgery - and the Dutchman will not play again for several months.
Gabriel Jesus
Status: Out
Type of injury: Knee
Possible return date: September 16 (vs. Everton)
Likewise, Gabriel Jesus has gone under the knife to address a knee problem, but the Brazilian striker will not be sidelined for as long as Timber and could make his comeback in the middle of next month.
Oleksandr Zinchenko
Status: Minor doubt
Type of injury: Calf
Possible return date: August 21 (vs. Crystal Palace)
Oleksandr Zinchenko is yet to play for the Gunners this season due to a calf problem, but he is now back in full training and in with a strong chance of deputising for Timber on Monday night.
Mohamed Elneny
Status: Out
Type of injury: Knee
Possible return date: Unknown
Mohamed Elneny welcomes Timber into the long-term knee injury club, and the Egyptian midfielder is still on the road to recovery from the operation he underwent at the end of January.
Folarin Balogun
Status: Minor doubt
Type of injury: Foot
Possible return date: August 21 (vs. Crystal Palace)
Folarin Balogun has not been seen in an Arsenal shirt since picking up a foot injury in pre-season, but the American striker is expected to head for the exit door in the coming weeks either way.
Albert Sambi Lokonga
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Similarly, Albert Sambi Lokonga is working his way back from a muscular injury, but the out-of-favour Belgian would be unlikely to force his way into a matchday squad if fully fit.
ARSENAL'S SUSPENSION LIST
Arsenal have no players suspended for this match.