Both sides are separated by three points, with the hosts in 11th place while the visitors are 13th in the Turkish Super Lig table.
Match preview
Adana Demirspor head into this clash after a 4-2 defeat to Fenerbahce, ending their three-match unbeaten run in the Super Lig.
Prior to the defeat, the Blue Lightnings had not lost in four games, including a 2-1 victory against Hatayspor in a friendly.
Hikmet Karaman's side are currently eight points clear of the relegation zone and will hope to extend that gap with seven games remaining.
Adana's strength lies in their home form this season, as they are the fourth-best team on home soil with 30 points from 15 matches. Having won their last two home games, the Blue Lightnings will be looking to make it three in a row.
However, their home record against Saturday's opponents is poor. They have lost four of the six games played between them at the New Adana Stadium, drawing one and winning just one.
Kayserispor are winless in four consecutive matches, having lost 2-0 to Kasimpasa at Kadir Has Sehir Stadyumu last time out.
Burak Yılmaz's side finished the game with ten men after Kartal Yilmaz was sent off for two yellow cards within seven minutes in the first half.
The Anatolian Stars have struggled for goals recently, scoring just once in their previous four matches, a period that has seen them pick up only one point.
With just seven games left and only five points above the relegation zone, Yilmaz will need to find a solution to Kayserispor's attacking woes if his side are to avoid the drop.
Having scored in all of their previous 15 games against Adana, the Anatolian Stars will hope their dominance in this fixture continues on Saturday.
Adana Demirspor Turkish Super Lig form:
D
L
W
D
W
L
Kayserispor Turkish Super Lig form:
W
W
L
D
L
L
Team News
Adana have close to a full squad available for this match, with only Nabil Alioui being a doubt as he is dealing with a thigh injury.
Youcef Atal should return to the XI after missing the last match through a suspension for his red card Sivasspor.
Mario Balotelli, who scored in the loss to Fenerbahce, is expected to lead the line once again with Stiven Mendoza and Yusuf Sari making up the three-man attack.
Yilmaz is out for the visitors, as he serves a suspension for getting sent off in the defeat to Kasimpasa last time out.
Anthony Uzodimma and Majid Hosseini will still be out of action with long-term injuries, with neither expected back in the near future.
Adana Demirspor possible starting lineup:
Mahammadaliyev; Atal, Gravillon, Guler, Erdogan; Akbaba, Maestro, Erdogan; Mendoza, Balotelli, Sari
Kayserispor possible starting lineup:
Bayazit; Kaldirim, Kolovetsios, Attamah, Carole; Yilmaz, Bourabia; Civelek, Karimi, Cardoso; Nazon