The Italian giants have dispatched the teams standing in their way so far and now face off in a massive European clash, with both legs at the San Siro.
This is the fifth time the Milan sides have faced each other in European competition, but it is the first at this stage since 2003.
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AC Milan vs Inter Milan: talkSPORT coverage
This Champions League semi-final first-leg clash will kick-off at the San Siro at 8pm on Wednesday, May 10.
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talkSPORT will have live commentary from northern Italy, with Hugh Woozencroft serving as your presenter.
Commentary will then come from Sam Matterface and Danny Mills.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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AC Milan vs Inter Milan: Teams
AC Milan: Maignan, Calabria, Tomori, Kjaer, Hernandez, Krunic, Tonali, Bennacer, Diaz, Saelemaekers, Giroud
Subs: Miranta, Nava, Ballo, Rebic, Kalulu, Origi, Thiaw, Pobega, Gabbia, Messias, De Ketelaere
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Inter Milan: Onana, Darmian, Acerbi, Bastoni, Dimarco, Dumfries, Barella, Calhanoglu, Mkhitaryan, Dzeko, Martinez
Subs: Handanovic, Cordaz, Gosens, De Vrij, Correa, Brozovic, Lukaku, Gagliardini, Bellanova, Asllani, D'Ambrosio, Zanotti