The attacker has netted six times in 11 Premier League matches against Wolves, with that total making him the all-time leading goalscorer in matches between the two sides in the competition.
Bowen is again set to be joined by Mohammed Kudus in the final third of the field, as Michail Antonio and Niclas Fullkrug remain unavailable for selection.
Crysencio Summerville is also sidelined, as is Vladimir Coufal, meaning that Emerson Palmieri and Aaron Wan-Bissaka could feature as the wing-backs for West Ham at Molineux.
Head coach Graham Potter is likely to name an unchanged side from the clash with Everton before the international break, including a position in the middle of midfield for Lucas Paqueta.
Carlos Soler and Guido Rodriguez are also options, while Evan Ferguson will be in Potter's thinking when it comes to the forward roles, but it might be a case of same again from the clash at Goodison Park.
West Ham United possible starting lineup: Areola; Todibo, Mavropanos, Kilman; Wan-Bissaka, Paqueta, Ward-Prowse, Soucek, Emerson; Kudus, Bowen
Written by
Matt Law