The Citizens are known to be without ACL victim Rodri and Oscar Bobb (leg fracture), but Kevin De Bruyne (groin) and Nathan Ake (thigh) might both be ready to return from their afflictions.
Guardiola will be expected to give an update on their respective conditions when he faces the media on Friday, but even if both men are given the green light from the medical team, they may be kept in reserve after their lengthy layoffs.
Instead, the reigning champions could put out a near identical XI to the one that bested Fulham 3-2 two weekends ago, as Erling Haaland bids to replicate his astonishing four-goal showing against Wolves from May's 5-1 thumping.
Norway's all-time top male scorer has eight strikes to his name from just four matches against Wolves, but only one of those has come away from home, and he should be supported by Bernardo Silva and Phil Foden once more.
However, a fierce battle is brewing on the left-hand side between Jeremy Doku and Jack Grealish, the former of whom scored a delightful goal against Fulham, while the latter shone for England in their UEFA Nations League beating of Finland.
Doku might just edge it on this occasion, but the pairing of Mateo Kovacic and Ilkay Gundogan should remain untouched, and the same goes for Rico Lewis, Josko Gvardiol, Ruben Dias, Manuel Akanji and Ederson in defence.
Manchester City possible starting lineup:
Ederson; Lewis, Akanji, Dias, Gvardiol; Kovacic, Gundogan; Silva, Foden, Doku; Haaland