The Red Devils held on to a 1-1 draw last week after a penalty from Mikel Oyarzabal canceled out Joshua Zirkzee's goal.
But at Old Trafford, it was a different story for Ruben Amorim's men.
Man United cruised to a 4-1 win over their opponents who ended the game with ten men.
Bruno Fernandes was the hero as he scored a hat-trick and also made a piece of European history.
And the Red Devils know exactly who they are facing next.
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Who could Man United face?
Man United beat Real Sociedad will face Lyon.
Lyon were 3-1 up on aggregate after the first leg of their tie against FCSB last week.
The French side were heading towards a draw until the final five minutes when striker Malick Fofana scored two in three minutes to claim a healthy lead.
But just like Man United, the French side battered their opponents on Thursday evening.
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Georges Mikautadze scored twice, while Ernest Numah also bagged a double, with Rayan Cherki grabbing two assists.
Should Amorim's side beat Lyon, then a potential semi-final against Rangers could be on the cards.
Jose Mourinho's Fenerbahce were beaten by Rangers on penalties after a 3-3 draw on aggregate.
The Scottish giants will now face Athletic Bilbao, with one of those two playing the Red Devils in the semis should they make it.
An all-Premier League final against Tottenham is possible, but Frankfurt and Lazio are sure to be contenders to go all the way.
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Europa League quarter-finals
Tottenham vs Eintracht Frankfurt
Bodoe/Glimt vs Lazio
Rangers vs Athletic Bilbao
Lyon vs Man United