The Red Devils captain was not involved against Fenerbahce in the Europa League on Thursday evening due to a European suspension, but he is back in the XI here, as Erik ten Hag's side resume their league campaign.
Head coach Ten Hag has named the same team that took to the field for the first whistle against Brentford last weekend, with Rasmus Hojlund and Casemiro also coming back into the side.
Alejandro Garnacho will play off the right, while Noussair Mazraoui is back in defence, having operated as a number 10 in the 1-1 draw with Fenerbahce last time out.
Jonny Evans is back on the bench for the 20-time English champions after recovering from injury.
As for West Ham, Mohammed Kudus's suspension has opened the door for Carlos Soler to come into the XI, while there are also returns to the side for Edson Alvarez, Lukasz Fabianski and Konstantinos Mavropanos.
Niclas Fullkrug is the home side's only absentee through injury, and it is unclear when the striker, who arrived from Borussia Dortmund over the summer, could return.
West Ham United: Fabianski; Wan-Bissaka, Mavropanos, Kilman, Emerson; Alvarez, Rodriguez; Bowen, Paqueta, Soler; Antonio
Subs: Areola, Cresswell, Coufal, Summerville, Guilherme, Ings, Todibo, Soucek, Irving
Manchester United: Onana; Mazraoui, De Ligt, Martinez, Dalot; Casemiro, Eriksen, Fernandes; Garnacho, Hojlund, Rashford
Subs: Bayindir, Amass, Evans, Lindelof, Fletcher, Ugarte, Amad, Wheatley, Zirkzee