Pep Guardiola's side will enter the match off the back of a 1-0 victory over Southampton in the league, with the result moving them two points clear at the top of the Premier League table.
The Citizens, who recorded a 2-1 victory over Watford in the last stage of the competition, are eight-time winners of the League Cup, with their last success in the competition coming back in 2020-21.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with Ange Postecoglou's side at the Tottenham Hotspur Stadium.
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Man City will be without the services of Rodri for the rest of the campaign after he suffered knee ligament damage in the clash with Arsenal earlier this season.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: Unknown
Oscar Bobb sustained a leg fracture ahead of the 2024-25 campaign, but he is now in the latter stages of his recovery, with Guardiola recently revealing that the attacker is targeting a return between January and February of next year.
Kevin De Bruyne
Status: Out
Type of injury: Groin
Possible return date: Unknown
De Bruyne has missed Man City's last eight matches with a groin injury; the Belgium international has returned to training, but it is still unclear when the experienced attacker will be available for selection.
Kyle Walker
Status: Out
Type of injury: Knee
Possible return date: Unknown
Walker, who has only featured on seven occasions this season, was again absent against Southampton on Saturday due to a knee problem, and it is unclear when the England international will be available for selection once again.
Jack Grealish
Status: Out
Type of injury: Knock
Possible return date: November 2 (vs. Bournemouth)
Grealish will again be unavailable for selection against Tottenham in the EFL Cup, but the England international should be fit for Man City's clash with Bournemouth in the Premier League on November 2.
Jeremy Doku
Status: Out
Type of injury: Muscle
Possible return date: November 9 (vs. Brighton)
Doku was another absentee against Southampton, with the attacker dealing with an unspecified knock, and Guardiola has said that he will be out for longer than Grealish, suggesting at a potential return the week after the Englishman.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.