The Blues were held to a 1-1 draw by Crystal Palace before the international break, but they beat Bournemouth 1-0 last weekend.
Enzo Maresca's side are eighth in the Premier League table, boasting seven points from their first four matches of the 2024-25 campaign.
Here, Sports Mole rounds up Chelsea's injury and suspension news ahead of their clash with West Ham, who are 14th in England's top flight, having collected four points from their first four matches.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
James was heavily involved in Chelsea's pre-season friendlies, but he suffered yet another hamstring issue ahead of the 2024-25 campaign, and the club captain remains on the sidelines, with a return date not being set by the club.
Romeo Lavia
Status: Minor doubt
Type of injury: Hamstring
Possible return date: September 21 (vs. West Ham)
Lavia was close to featuring against Bournemouth last weekend, and there is a strong chance that the midfielder, who has recently been out with a hamstring problem, will be back on the field against West Ham.
Malo Gusto
Status: Minor doubt
Type of injury: Thigh
Possible return date: September 21 (vs. West Ham)
Gusto missed out against Bournemouth due to a thigh problem, but the defender has been back in training this week, and he is expected to be back in the squad against the Hammers.
Enzo Fernandez
Status: Minor doubt
Type of injury: Illness
Possible return date: September 21 (vs. West Ham)
Fernandez was not involved in Chelsea's clash with Bournemouth last weekend due to illness, but he has been back in training this week and should be involved here.
Kiernan Dewsbury-Hall
Status: Minor doubt
Type of injury: Illness
Possible return date: September 21 (vs. West Ham)
Dewsbury-Hall was also missing from the squad against Bournemouth due to illness, but the 26-year-old is set to return for the London derby.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for this fixture.