The Reds scraped past Nottingham Forest in a five-goal thriller at Anfield on Saturday but remain nine points adrift of Manchester United.
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Jurgen Klopp's men have even played a game more than fourth placed United - who face Tottenham away this week - but successive Premier League wins have kept their European hopes alive.
Meanwhile, West Ham thumped Bournemouth 4-0 at the weekend to continue their charge away from the relegation zone.
West Ham v Liverpool: talkSPORT coverage
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This Premier League clash will take place on Wednesday, April 26.
Kick-off at the London Stadium is scheduled for 7:45pm.
talkSPORT 2 will have live and EXCLUSIVE coverage from east London.
Commentary comes from Ian Danter and former England striker Dean Ashton.
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To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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West Ham v Liverpool: Team news
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The Irons will continue to be without Gianluca Scamacca but Angelo Ogbonna was fit enough to return to the bench against Bournemouth.
The hosts otherwise have no fresh injury concerns to contend with, as Danny Ings fights to feature against his former club.
Liverpool have a host of absentees, with Roberto Firmino the latest to join those in the Reds treatment room.
Naby Keita, Stefan Bajcetic and Calvin Ramsay all remain sidelined but Klopp may choose to freshen up his attack with Darwin Nunez waiting in the wings.
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West Ham v Liverpool: What has been said?
Jota speaking after Liverpool secured back-to-back wins: "It gives confidence to the team.
"We believe in what we are doing and against Arsenal the win was there for us in the end but unfortunately we could not take it.
"But it's two in a row already and this is the only way we can fight to be in the highest position in the table."
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West Ham v Liverpool: Match facts
Saïd Benrahma has been directly involved in 5.4 shots per 90 in the Premier League this season (3.3 shots and 2.1 chances created), the most by a West Ham player in a single campaign (500+ mins played) since Dimitri Payet in 2016-17 (7.7 per 90).
Diogo Jota - who has lost none of the 35 Premier League games he's scored in - has scored braces in each of his last two appearances for Liverpool. The last player to net 2+ goals in more consecutive league games for the Reds was Luis Suárez in December 2013 (a run of four, with the second game in that run coming against West Ham).
Mohamed Salah has been directly involved in half of Liverpool's 20 away goals in the Premier League this season, scoring eight and assisting two. The Egyptian has also been involved in seven goals in five league games against West Ham at the London Stadium (5 goals, 2 assists), with Raheem Sterling (9) the only visiting player to be involved in more at the ground.
Against no side has West Ham's Pablo Fornals scored more Premier League goals than he has against Liverpool (3), netting to put the Hammers 2-1 ahead in their 3-2 victory in this exact fixture last season.
West Ham will be looking to win consecutive Premier League games for just the second time this season (previously in October), after their 4-0 win at Bournemouth last time out. However, the Hammers have only won two of their last 20 games against opponents starting the day in the top half of the Premier League table (D5 L13), and both of those victories were against Fulham.
Liverpool scored more goals in their 6-1 win in their last away league match against Leeds than they had in their previous eight on the road combined (4 - W1 D2 L5). Only once this season have they won consecutive away league games, doing so in November/December against Spurs and Aston Villa.
After losing three consecutive home league games in November/December, West Ham have lost just one of their last seven at the London Stadium (W3 D3), scoring at least once in each match.
Liverpool have won just one of their six Premier League away games against London sides this season (D3 L2), beating Spurs 2-1 in November. Having scored in 27 consecutive league games in the capital between August 2018 and January this year, Liverpool's last two visits have both finished 0-0.
Liverpool have won 10 of their last 12 Premier League games against West Ham, with the exceptions both coming at the London Stadium (1-1 in February 2019, 2-3 in November 2021).
West Ham won this exact fixture 3-2 last season, last winning consecutive home games against Liverpool in 2014-15/2015-16.