The 31-year-old joined Villarreal from Real Betis over the summer, and he has made a strong start to his time at the club, scoring three goals in five appearances.
Perez hit the winner in Villarreal's 2-1 success over Mallorca last weekend, and the Spain international is again set to be joined by fellow summer arrival Thierno Barry in the final third of the field.
Villarreal will be without the services of four players through injury, with Willy Kambwala, Gerard Moreno, Juan Foyth and Alfonso Pedraza on the sidelines.
Head coach Marcelino could decide to select the same XI from the game against Mallorca, with Santi Comesana and Dani Parejo potentially operating as the midfield two.
Kiko Femenia and Sergi Cardona should continue in the full-back areas, while Alex Baena is expected to be given the nod down the left.
Ilias Akhomach started his professional career at Barcelona, and the 20-year-old is set to take to the field against his former club this weekend.
Villarreal possible starting lineup: Conde; Femenia, Albiol, Costa, S Cardona; Akhomach, Comesana, Parejo, Baena; Perez, Barry