The Reds breezed past Brentford at the Gtech Community Stadium as they won 4-1 to remain top of the Premier League table.
And centre-back Van Dijk once again starred for the Merseyside outfit, as he has done since joining from Southampton in 2018.
In what was a landmark milestone for Van Dijk, he has now won 171 out of his 250 appearances for Liverpool in all competitions.
It is the most victories out of any other Liverpool player to reach that amount of matches, beating teammate Trent Alexander-Arnold's previous record of 168 wins.
And speaking in his post-match interview to TNT Sports, the 64-cap Netherlands international was all smiles after finding out about the historic stat.
Van Dijk, who has also lost just one Premier League match at Anfield, said of the feat: "I play with great players!
"I'm proud to be a Liverpool player, captain, part of the history of the club. It's amazing.
"I enjoy each and every day, and also coming out of the tunnel at Anfield or coming out here, leading out the boys.
"When I was a young little boy, I always dreamed of playing in the Premier League.
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"Going out there and doing what I love, it's amazing, and onto many more."
On his landmark appearance, he remarked: "Very pleased! I had no clue that I was playing my 250th game for Liverpool.
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"It's a proud moment for me and my family."
Attention for Liverpool will now turn towards Wednesday night's home clash against Luton.
And Jurgen Klopp's men will have revenge on their mind having been held to a 1-1 draw at Kenilworth Road earlier in the season.