Spurs suffered a humiliating fifth round exit to Championship side Middlesbrough last week to continue their mixed form under Antonio Conte.
Everton meanwhile put Boreham Wood to the sword to book their FA Cup quarter-final spot but are struggling for form in the league.
The Toffees are winless in their last 10 Premier League games away from home and are just one point above the relegation zone.
Tottenham v Everton: Date and time
This Premier League clash will take place on Monday, March 7.
The top-flight contest at the Tottenham Hotspur Stadium will kick-off at 8pm.
Everton held Spurs to a 0-0 draw in the reverse fixture at Goodison Park in November in what was Conte's first game in charge.
Tottenham v Everton: Live stream and TV Channel
This match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League with live coverage starting from 7pm.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £9.99.
Tottenham v Everton: Team news
Tottenham have Rodrigo Bentancur and Lucas Moura back for the visit of Everton.
Bentancur has been out with an ankle injury and Moura has had a dead leg but both could start tonight.
Oliver Skipp and Japhet Tanganga will miss out.
Everton striker Dominic Calvert-Lewin is likely to be back after missing the last two matches with a groin problem.
Demarai Gray should be available after he sat out the win over Boreham Wood with a fever while Andre Gomes is also back after a thigh problem.
Ben Godfrey is not set to return to training until next week due to a hamstring problem.
Tottenham v Everton: What has been said?
Conte has played down the chances of Dele Alli coming back to haunt Tottenham.
"I don't remember a player that when he went away, came back with a great spirit of revenge," Conte said.
"Honestly, I don't remember one. During my coaching, I always try to be honest with the players and give all the players the possibility to show me that they deserve to play.
"I don't remember a player that had their revenge with me. What happens usually is that when players went away they went down, not up."