Nuno Espirito Santo's side have marched to three consecutive 1-0 victories over Manchester City, Wolverhampton Wanderers and Watford so far, with Son Heung-min scoring the winner against the latter just before the international break.
The Lilywhites have stormed to the top of the rankings as the only team with maximum points so far, while they are also the only team in the division yet to concede ahead of gameweek four.
Here, Sports Mole rounds up all of Tottenham's latest injury and suspension news ahead of the contest.
Son Heung-min
Status: Major doubt
Type of injury: Calf
Possible return date: September 11 (vs. Palace)
Star attacker Son Heung-min sustained a calf injury while on international duty with South Korea and missed their midweek win over Lebanon. The 29-year-old's problem will need to be assessed ahead of this fixture.
Tanguy Ndombele
Status: Out
Type of injury: Other
Possible return date: Unknown
Tanguy Ndombele has been frozen out of the team by Santo but did not secure a move away in the most recent transfer window. With the midfielder still on the books at Spurs, it remains to be seen if he will be reintegrated back into the fold.
Joe Rodon
Status: Minor doubt
Type of injury: Thigh
Possible return date: September 11 (vs. Crystal Palace)
Joe Rodon's thigh injury did not prevent him from linking up with the Wales squad during the international break, and the defender could be in contention for the weekend after returning to full training.
Davinson Sanchez
Status: Out
Type of injury: Other
Possible return date: September 19 (vs. Chelsea)
Davinson Sanchez is one of three players in hot water with Spurs after electing to link up with Colombia for the international break. The defender has been released from his national squad, but quarantine measures will prevent him from featuring this weekend.
Giovani Lo Celso
Status: Out
Type of injury: Other
Possible return date: September 19 (vs. Chelsea)
Giovani Lo Celso was one of four Argentinian players targeted by Brazilian health authorities after allegedly failing to self-isolate upon arrival from the UK - which came to a head during their World Cup Qualifying battle with the Selecao - and the midfielder will miss this game.
Cristian Romero
Status: Out
Type of injury: Other
Possible return date: September 19 (vs. Chelsea)
Cristian Romero was also at the centre of the Argentina-Brazil debacle alongside his teammate Lo Celso, and the defender will play no part against Palace as he self-isolates.
SPURS' SUSPENSION LIST
Tottenham have no players suspended for this contest.