The Red Devils are currently fifth in the table, collecting 15 points from their opening eight matches, while Newcastle are sixth with 14 points, and here Sports Mole rounds up the team news.
MANCHESTER UNITED vs. NEWCASTLE UNITED
MANCHESTER UNITED
Out: Harry Maguire (hamstring), Scott McTominay (suspended), Martin Dubravka (ineligible), Donny van de Beek (muscle), Aaron Wan-Bissaka (muscle), Mason Greenwood (suspended), Brandon Williams (unknown), Axel Tuanzebe (unknown)
Doubtful: Anthony Martial (back)
Sports Mole's predicted XI: De Gea; Dalot, Varane, Martinez, Shaw; Fernandes, Casemiro, Eriksen; Antony, Ronaldo, Rashford
NEWCASTLE UNITED
Out: Karl Darlow (ankle), Alexander Isak (thigh), Jonjo Shelvey (thigh), Matt Ritchie (calf), Emil Krafth (knee)
Doubtful: None
Sports Mole's predicted XI: Pope; Trippier, Schar, Botman, Burn; S Longstaff, Guimaraes, Willock; Saint-Maximin, Wilson, Almiron
For data analysis of the most likely results, scorelines and more for this match please click here.