Seattle Sounders, meanwhile, head to Missouri in search of a second victory on the bounce having returned to winning ways in their most recent involvement.
Match preview
St Louis City were beaten for the second time in the space of three days following a 3-1 defeat against FC Cincinnati in Sunday's meeting at TQL Stadium.
Goals from Luciano Acosta and Yuya Kubo left Bradley Carnell's men down by two but they managed to halve the deficit thanks to Matt Miazga's own goal after which Sergio Santos sealed the deal.
Consequently, St Louis City remain ninth in the Western Conference of the MLS table, three points shy of Vancouver Whitecaps in the race for the final guaranteed playoff spot.
Awaiting them next is the challenge of an opposing outfit who came out on top in both of the previous two editions of this fixture by a combined score of 5-0.
Fresh from seeing their seven-game unbeaten home run come to an end, Sunday's hosts set out to avoid back to back defeats on their own patch for the first time since October.
Seattle Sounders secured safe passage into the quarter-finals of the US Open Cup thanks to a 2-1 victory over Phoenix Rising at Lumen Field on Thursday.
Brian Schmetzer's men went into the interval trailing to Remi Cabral's opener before second-half strikes from Alexander Roldan and Kossa-Rienzi Kalani turned the game around.
This came off the back of a 1-1 stalemate against Vancouver Whitecaps which left The Rave Green 10th in the Western Conference standings.
Boasting just two wins from their last 10 games on the road across all competitions, Sundays visitors have struggled away from home of late and will be keen to turn things around.
St Louis City Major League Soccer form:
W
D
D
W
L
L
Seattle Sounders Major League Soccer form:
L
W
D
W
L
D
Team News
Thirty-year-old Joshua Yaro is ruled out for St Louis City through a hamstring injury he picked up against FC Dallas in the first week of April.
Eduard Lowen will be pushing for a first start for the hosts in over two months having made his return to action from an injury layoff last time out.
Seattle Sounders' Nouhou Tolo is suspended after he was sent off for two bookable offences in Sunday's 1-1 stalemate against Phoenix Rising.
Braudilio Rodrigues remains without an appearance for the visitors since the turn of the year through a torn muscle but the forward is closing in on a return to action.
St Louis City possible starting lineup:
Burki; Dhyr, Nilsson, Hiebert, Watts; Pompeu, Kijima, Blom, Jackson; Adeniran, Klauss
Seattle Sounders possible starting lineup:
Frei; Baker, Bell, Ragen, Kitahara; Paulo, Leyva; Chu, Rusnak, Minoungou; Musovski
We say: St Louis City 1-2 Seattle Sounders
Seattle Sounders have enjoyed the better of this fixture and are the more in-form side heading into this weekend's contest. We just about fancy the away side to carry the day come the sound of the final whistle.