The Irons snapped a five-game winless run with a 4-1 trouncing of Ipswich Town before the international break, where Michail Antonio scored West Ham's quickest Premier League goal on record after just 48 seconds.
The Jamaican may have added competition from Niclas Fullkrug to lead the line this week - the Germany international is nearing a comeback from an Achilles problem - but his exceptional record against Spurs will benefit his chances of a derby start.
Indeed, Antonio has scored six goals against Tottenham in the past - his best record against a single opponent in the Premier League - and five of those strikes have been the opening goal.
Only Manchester United legend Ryan Giggs (six) has scored more opening goals against Tottenham in the Premier League, and Antonio should spearhead an offensive quartet also comprising Jarrod Bowen, Lucas Paqueta and Mohammed Kudus.
Tomas Soucek and Guido Rodriguez ought to link arms in the deeper midfield slots, while Aaron Wan-Bissaka, Jean-Clair Todibo, Max Kilman and Emerson Palmieri will be tasked with protecting Alphonse Areola.
West Ham United possible starting lineup:
Areola; Wan-Bissaka, Todibo, Kilman, Emerson; Rodriguez, Soucek; Bowen, Paqueta, Kudus; Antonio