The visitors are 19 points shy of safety with 24 left to play for, while their hosts occupy a humiliating 14th place in the Premier League table, and here Sports Mole rounds up the team news for the two clubs.
TOTTENHAM HOTSPUR vs. SOUTHAMPTON
TOTTENHAM HOTSPUR
Out: Radu Dragusin (ACL), Dejan Kulusevski (foot), Kevin Danso (hamstring)
Doubtful: Richarlison (calf)
Sports Mole's predicted XI: Vicario; Porro, Romero, Gray, Udogie; Sarr, Bissouma, Maddison; Johnson, Solanke, Tel
SOUTHAMPTON
Out: Flynn Downes (suspended), Juan Larios (fitness), Ross Stewart (fitness), Will Smallbone (groin)
Doubtful: Paul Onuachu (ankle)
Sports Mole's predicted XI: Ramsdale; Harwood-Bellis, Bednarek, Bella-Kotchap; Sugawara, Aribo, Ugochukwu, Walker-Peters; Fernandes; Archer, Dibling
For data analysis of the most likely results, scorelines and more for this match please click here. Written by
Ben Knapton