Ange Postecoglou's side will look to recover from dropping their first points in the league phase away to Galatasaray last time out, while this will be Claudio Ranieri's first European game in charge since rejoining the club as manager for the third time earlier this month.
TOTTENHAM HOTSPUR vs. ROMA
TOTTENHAM HOTSPUR
Out: Guglielmo Vicario (ankle), Micky van de Ven (hamstring), Mikey Moore (illness), Will Lankshear (suspended), Richarlison (hamstring), Wilson Odobert (hamstring)
Doubtful: Cristian Romero (foot)
Sports Mole's predicted XI: Forster; Spence, Dragusin, Davies, Gray; Sarr, Bentancur, Bergvall; Johnson, Solanke, Werner
ROMA
Out: Eldor Shomurodov (muscle)
Doubtful: Mario Hermoso (muscle), Alexis Saelemaekers (ankle)
Sports Mole's predicted XI: Svilar; Celik, Mancini, Hummels, Angelino; Soule, Baldanzi, Cristante, Zalewski; Dybala, Dovbyk
For data analysis of the most likely results, scorelines and more for this match please click here.