The Lilywhites triggered the dismissal of ex-Southampton boss Russell Martin by thrashing the Saints 5-0 on Sunday, scoring five goals in the first half of a Premier League game for the first time ever.
Ange Postecoglou's men have also eliminated Coventry City and Manchester City to make it this far in the EFL Cup, as they chase a first slice of silverware since last conquering this tournament in 2008.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of their showdown with the Red Devils, who come into the quarter-final on the back of a 2-1 Manchester derby win over Manchester City.
Destiny Udogie
Status: Major doubt
Type of injury: Thigh
Possible return date: December 19 (vs. Man United)
The only negative aspect of Sunday's win over Southampton was the thigh injury to Destiny Udogie, who had to come off in the first half, and it remains to be seen if he is cleared to feature in Thursday's quarter-final.
Guglielmo Vicario
Status: Out
Type of injury: Ankle
Possible return date: March 8 (vs. Bournemouth)
One player who will definitely miss the clash, Guglielmo Vicario fractured his ankle in the 4-0 win over Manchester City last month, and Spurs' number one will not return until the spring.
Cristian Romero
Status: Out
Type of injury: Thigh
Possible return date: January 19 (vs. Everton)
On his comeback appearance from a toe injury, Cristian Romero injured his thigh in the 4-3 loss to Chelsea two weekends ago, and there are fears that the South American will be missing for as long as six weeks.
Richarlison
Status: Out
Type of injury: Hamstring
Possible return date: January 15 (vs. Arsenal)
Struggling striker Richarlison is also expected to be on the treatment table until the middle of January due to his own hamstring problem, but Spurs will not rush him back given his history of problems.
Micky van de Ven
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
The luckless Micky van de Ven picked up a new hamstring injury not long after Romero hurt himself against Chelsea; Postecoglou was initially hopeful that it was not severe, but there is no chance he will be involved in the quarter-final.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Wilson Odobert was beginning to find his feet again after one hamstring injury before sustaining another, and the Frenchman is currently on the mend from surgery with no timeframe on his recovery.
Mikey Moore
Status: Out
Type of injury: Illness
Possible return date: Unknown
Teenage protege Mikey Moore has not played since the end of October owing to a troubling illness, and the winger is still working his way back from the infection.
Ben Davies
Status: Out
Type of injury: Hamstring
Possible return date: December 29 (vs. Wolverhampton Wanderers)
Ben Davies was a casualty of the loss to Bournemouth earlier this month, picking up a hamstring problem on the South Coast, but a return before the end of the year has not been ruled out.
TOTTENHAM'S SUSPENSION LIST
Rodrigo Bentancur
Return date: December 26 (vs. Nottingham Forest)
Yves Bissouma is back from a ban this week, but Rodrigo Bentancur serves the penultimate of his seven-game suspension for his offensive comment towards Son Heung-min and South Koreans.
Written by
Ben Knapton