The Lilywhites made it three wins on the bounce in the top division with a 4-1 crushing of Ipswich Town over the weekend, where only six players were missing through injury compared to 11 or 12 in previous fixtures over the winter.
One of the sextet - Timo Werner - might be back from his hamstring concern this week, but Radu Dragusin (ACL), Dominic Solanke (knee), Richarlison (calf), Cristian Romero (thigh) and Micky van de Ven (thigh) are still out.
Ben Davies's absence from the matchday squad at Portman Road also raised eyebrows, but the Welshman was simply being rested and could now make a swift return to the backline, thus offering Archie Gray a night off.
Pedro Porro can also expect a recall to the rearguard, most likely in place of Destiny Udogie given Djed Spence's stellar form in recent weeks, which he continued with a goal in Saturday's emphatic triumph.
Further forward, fresh legs could arrive in midfield in the shape of James Maddison and Pape Sarr, as Postecoglou pushes Dejan Kulusevski into a more familiar right-wing position, potentially at Mathys Tel's expense.
The Bayern Munich loanee could not directly contribute to the win at Ipswich, where Brennan Johnson scored twice from a pair of Son Heung-min assists, and the former could now start as the attacking focal point as Son and Kulusevski flank him.
Tottenham Hotspur possible starting lineup:
Vicario; Porro, Danso, Davies, Spence; Maddison, Bentancur, Sarr; Kulusevski, Johnson, Son
Written by
Ben Knapton