Since bagging a goal during the 4-1 hammering of West Ham United in the Premier League on October 19, the South Korean has missed the last two matches for the Lilywhites.
In the absence of the left winger, Mikey Moore made his full top-flight debut during the loss to Crystal Palace on Sunday, with the 17-year-old a candidate to start against the Citizens in the EFL Cup.
Guglielmo Vicario was massively apologetic to the travelling support at Selhurst Park in the aftermath of insipid performance last time out, with the Italian likely to be rotated out of net to accomodate for backup goalkeeper Fraser Forster.
With third-round goalscorer Djed Spence sidelined due to a groin issue, Ange Postecoglou could start first-choice right-back Pedro Porro, although there is a case for summer arrival Archie Gray to operate in the backline.
A surprise omission from the Premier League lineup at Palace on Sunday, Pape Sarr could be promoted from the bench at the expense of Dejan Kulusevski or Yves Bissouma.
Big-money signing Dominic Solanke might drop out of the XI to make room for Richarlison, who has previously shown his capability to lead the line for the Lilywhites.
Tottenham Hotspur possible starting lineup: Forster; Gray, Dragusin, Davies, Udogie; Sarr, Betancur, Maddison; Werner, Johnson, Richarlison