With four away matches to come over the next 11 days for the Citizens, Pep Guardiola is expected to heavily rotate his side from the one which narrowly beat Southampton in the Premier League on Saturday afternoon.
Stefan Ortega will take the spot in between the sticks as Ederson drops to the bench, whilst defenders such as Nathan Ake and John Stones could provide a sprinkling of first-team steel to the back four.
With Rodri sidelined for the remainder of the season with a cruciate ligament injury, the Citizens are exploring new options in the engine room, with 19-year-old Nico O'Reilly preparing to start at the Tottenham Hotspur Stadium.
Guardiola has stated that he is not willing to take any risks in terms of team selection for this EFL Cup clash, meaning that Erling Haaland, Manuel Akanji and Ruben Dias might not even feature in the matchday squad.
Both starting the third-round success over Watford last month, Jack Grealish (knock) and Jeremy Doku (discomfort) are occupying beds in the Man City medical room.
The Citizens have failed to provide specific return dates for Kyle Walker and Kevin De Bruyne, who are fighting back from thigh and groin issues respectively.
Manchester City possible starting lineup: Ortega; Lewis, Stones, Braithwaite; Ake, O'Reilly, Savio, McAtee, Gundogan, Nunes; Foden