The Lilywhites are aiming to bounce back quickly from a disappointing afternoon at Selhurst Park on Sunday afternoon, when Crystal Palace recorded their maiden win of the Premier League term at the expense of the visitors.
Winning four of their opening nine top-flight fixtures, Ange Postecoglou's side are occupying eighth place in the Premier League standings, five points behind Aston Villa in the lowest of the Champions League spots.
Tottenham will be striving for a morale-boosting win over Man City, and here Sports Mole wraps up the latest injury and suspension news for Spurs ahead of Wednesday's EFL Cup showdown.
Son Heung-min
Status: Major doubt
Type of injury: Thigh
Possible return date: November 3 (vs. Aston Villa)
Son has missed the last two matches of Tottenham versus AZ Alkmaar and Crystal Palace due to a thigh injury, meaning that it is highly unlikely that the South Korean will be risked on Wednesday night in the EFL Cup.
Djed Spence
Status: Major doubt
Type of injury: Groin
Possible return date: November 3 (vs. Aston Villa)
A last-minute scorer during the comeback success over Coventry City during the third round in September, Spence is set to miss the visit of Manchester City, although the right-back is scheduled for a return to training this week.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for Wednesday's match.